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血管性认知功能障碍患者血清PDGF、MMP-9、IL-6的动态变化及其临床意义

Dynamic changes and clinical significance of serum PDGF,MMP-9 and IL-6 in patients with vascular cognitive impairment
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摘要 目的探讨血管性认知功能障碍患者血清血小板源性生长因子(PDGF)、基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)的动态变化及其临床意义。方法68例血管性认知功能障碍患者为观察组[根据认知功能障碍程度分为血管性痴呆组(36例)及非痴呆型认知功能障碍组(32例)],同期70例无认知功能障碍的脑梗死患者为对照组。采用酶联免疫吸附法(ELISA)测定所有患者发病后24 h、7 d、14 d、1个月的血清PDGF、MMP-9、IL-6水平。比较观察组与对照组的PDGF、MMP-9、IL-6水平;比较血管性痴呆组与非痴呆型认知功能障碍组患者的PDGF、MMP-9、IL-6水平;分析血管性认知功能障碍患者的影响因素及血清PDGF、MMP-9、IL-6水平与血管性认知功能障碍的相关性。结果观察组患者发病后24 h、7 d、14 d、1个月、3个月的PDGF水平分别为(43.68±8.24)、(95.25±6.24)、(129.27±12.14)、(159.26±11.31)、(189.65±10.29)ng/ml,MMP-9水平分别为(233.38±28.24)、(243.68±23.24)、(258.68±30.36)、(265.47±30.48)、(281.54±32.47)ng/ml,IL-6水平分别为(6.98±3.52)、(7.58±1.56)、(9.33±1.56)、(10.26±1.46)、(12.34±1.22)ng/ml,均明显高于对照组的(37.43±7.56)、(175.23±18.24)、(5.36±2.43)ng/ml,差异具有统计学意义(P<0.05)。血管性痴呆组患者发病后24 h、7 d、14 d、1个月、3个月的PDGF、MMP-9、IL-6水平均明显高于非痴呆型认知功能障碍组,差异具有统计学意义(P<0.05)。Logistic回归分析显示:血清PDGF、MMP-9、IL-6均是血管性认知功能障碍的独立危险因素(P<0.05)。Pearson相关分析显示:PDGF、MMP-9、IL-6水平与血管性认知功能障碍呈正相关(r=0.547、0.601、0.497,P<0.05)。结论血管性认知功能障碍患者血清PDGF、MMP-9、IL-6水平显著增高,且增高幅度与认知功能有关,预测血管性认知功能障碍的价值较高。 Objective To discuss the dynamic changes and clinical significance of serum plateletderived growth factor(PDGF),matrix metalloproteinase-9(MMP-9),interleukin-6(IL-6)in patients with vascular cognitive impairment.Methods 68 patients with vascular cognitive impairment were taken as the observation group[according to the degree of cognitive impairment,they were divided into vascular dementia group(36 cases)and non-dementia cognitive impairment group(32 cases)].In the same period,70 patients without vascular cognitive impairment were taken as the control group.The serum PDGF,MMP-9 and IL-6 levels were measured by enzyme-linked immunosorbent assay(ELISA)in all patients at 24 h,7 d,14 d and 1 month after onset.Comparison was made on the levels of PDGF,MMP-9,and IL-6 between the observation group and the control group,and between the vascular dementia group and the non-dementia cognitive impairment group.The influencing factors of patients with vascular cognitive impairment and the correlation between serum PDGF,MMP-9,IL-6 levels and vascular cognitive dysfunction were analyzed.Results In the observation group,the PDGF levels were(43.68±8.24),(95.25±6.24),(129.27±12.14),(159.26±11.31)and(189.65±10.29)ng/ml at 24 h,7 d,14 d and 1 month after onset,the levels of MMP-9 were(233.38±28.24),(243.68±23.24),(258.68±30.36),(265.47±30.48)and(281.54±32.47)ng/ml,and the levels of IL-6 were(6.98±3.52),(7.58±1.56),(9.33±1.56),(10.26±1.46)and(12.34±1.22)ng/ml,which were significantly higher than(37.43±7.56),(175.23±18.24),(5.36±2.43)ng/ml of the control group,and the differences were statistically significant(P<0.05).The levels of PDGF,MMP-9,and IL-6 in the vascular dementia group at 24 h,7 d,14 d,1 month,and 3 months after onset were significantly higher than those in the non-dementia cognitive impairment group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that serum PDGF,MMP-9 and IL-6 were independent risk factors for vascular cognitive impairment(P<0.05).Pearson corr
作者 周雪梅 王丽香 李运刚 贾文歆 于振江 夏英凯 ZHOU Xue-mei;WANG Li-xiang;LI Yun-gang(Department of Neurology,Laiwu Iron and Steel Group Co.,Ltd.Hospital,Laiwu 271126,China)
出处 《中国实用医药》 2021年第34期9-12,共4页 China Practical Medicine
基金 济南市卫生健康委科技计划项目(项目编号:2020-3-57),项目名称:血管性认知功能障碍患者血清PDGF、MMP-9、IL-6的动态变化及其临床意义。
关键词 血管性认知功能障碍 血小板源性生长因子 基质金属蛋白酶-9 白细胞介素-6 Vascular cognitive impairment Platelet-derived growth factor Matrix metalloproteinase-9 Interleukin-6
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