摘要
以无水甲醇、浓盐酸、浓硫酸、L-半胱氨酸盐酸盐一水物为原料,催化合成L-半胱氨酸甲酯盐酸盐,摩尔收率77.3%,通过^(1)H-NMR和红外光谱对产物进行了结构表征。该方法较使用酰氯的方法更加环保,反应时间短,清洁无污染,适合大规模生产L-半胱氨酸甲酯盐酸盐及其它氨基酸甲酯盐酸盐。本文从原料、设备、安全、环保、工艺的角度对产品工业化给出了建议。
Absolute methanol,concentrated hydrochloric acid,concentrated sulfuric acid and L-cysteine hydrochloride monohydrate were used as raw materials to synthesize L-cysteine methyl ester hydrochloride,and the mole yield was 77.3%.The structure of L-cysteine methyl ester hydrochloride was characterized by ^(1)H-NMR and IR.Compared with the general method catalyzed by acyl chlorides,this method was more environmentally friendly,shorter in reaction time,cleaner with pollution-free,more suitable for large-scale production of L-cysteine methyl ester hydrochloride and other amino acid methyl ester hydrochlorides.The advice on the industrialization of the product was given from the aspects of the raw material,equipment,safety,environmental protection and technology.
作者
王先兵
章平
何威
肖国安
甘飞
WANG Xian-bing;ZHANG Ping;HE Wei;XIAO Guo-an;GAN Fei(Shine Star(Hubei)Biological Engineering Co.,Ltd.,Hubei Jingzhou 434000,China)
出处
《广州化工》
CAS
2021年第24期34-36,共3页
GuangZhou Chemical Industry
关键词
氯化氢
L-半胱氨酸盐酸盐一水物
L-半胱氨酸甲酯盐酸盐
催化合成
hydrogen chloride
L-cysteine hydrochloride monohydrate
L-cysteine methyl ester hydrochloride
catalyzed synthesis
