摘要
目的:探讨固定剂量及变化剂量沙丁胺醇雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺通气功能的影响。方法:选取2017年10月~2018年12月AECOPD患者102例,采用单盲法进行分组,分为观察组和对照组,各51例。对照组采用固定剂量沙丁胺醇雾化吸入治疗,观察组采用变化剂量沙丁胺醇雾化吸入治疗。治疗10 d后,比较两组肺通气功能、不良反应发生率。结果:治疗前,两组FEV_(1)、FVC、FEV_(1)/FVC水平对比,差异无统计学意义(P>0.05);治疗10 d后,两组FEV_(1)、FVC、FEV_(1)/FVC水平与治疗前相比,均有所升高,差异具有统计学意义(P<0.05);治疗10 d后,观察组FEV_(1)(1.99±0.45)L、FVC(2.10±0.53)L、FEV_(1)/FVC(65.28±5.54)%水平与对照组[(1.87±0.43)L、(2.09±0.56)L、(64.81±5.49)%]相比,差异无统计学意义(P>0.05);观察组不良反应发生率(9.80%)较对照组(23.53%)低,差异有统计学意义(χ^(2)=4.744,P=0.029)。结论:固定剂量及变化剂量沙丁胺醇雾化吸入均可有效改善AECOPD患者肺通气功能,但变化剂量治疗可降低不良反应发生率,安全性较高,值得临床推广。
Objective To investigate the effects of fixed dose and variable dose salbutamol aerosol inhalation on pulmonary ventilation function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method 102 AECOPD patients in our hospital from October 2017 to December 2018 were selected and divided into observation group(51 cases)and control group(51 cases)by single blind method.The control group was treated with fixed dose salbutamol atomization inhalation,and the observation group was treated with variable dose salbutamol atomization inhalation.After 10 days of treatment,the pulmonary ventilation function and the incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in FEV_(1),FVC and FEV_(1)/FVC levels between the two groups(P>0.05);after 10 days of treatment,the levels of FEV_(1),FVC and FEV_(1)/FVC in the two groups were increased compared with those before treatment,and the difference was statistically significant(P<0.05);after 10 days of treatment,the levels of FEV_(1)(1.99±0.45)L,FVC(2.10±0.53)L and FEV_(1)/FVC(65.28±5.54)%in the observation group were significantly higher than those in the control group[(1.87±0.43)L、(2.09±0.56)L、(64.81±5.49)%],the difference was not statistically significant(P>0.05);the incidence of adverse reactions in the observation group(9.80%)was lower than that in the control group(23.53%),the difference was statistically significant(χ^(2)=4.744,P=0.029).Conclusion Fixed dose and variable dose salbutamol aerosol inhalation can effectively improve the pulmonary ventilation function of AECOPD patients,but the change dose treatment can reduce the incidence of adverse reactions,with high safety,which is worthy of clinical promotion.
作者
梁艳敏
LIANG Yan-min(Tianjin Ninghe district hospital,Tianjin 301500,China)
出处
《吉林医学》
CAS
2021年第12期2870-2872,共3页
Jilin Medical Journal
关键词
慢性阻塞性肺疾病急性加重期
沙丁胺醇
变化剂量
固定剂量
雾化吸入
肺通气功能
Acute exacerbation of chronic obstructive pulmonary disease
Salbutamol
Variable dose
Fixed dose
Aerosol inhalation
Pulmonary ventilation function
