摘要
目的系统评价肺部超声诊断结缔组织病相关间质性肺疾病的价值。方法计算机检索PubMed、Embase、Cochrane Library、CBM、CNKI、维普和万方数据库,搜集肺部超声诊断结缔组织病相关间质性肺疾病的相关文献,检索时间为建库至2020年10月1日。由两名研究人员依据纳入和排除标准筛选文献,使用QUADAS-2量表评价文献质量,采用RevMan 5.2、Stata 12.0和Meta-Disc 1.4统计软件分析肺部超声诊断结缔组织病相关间质性肺疾病的价值,计算合并敏感性、特异性、阳性似然比、阴性似然比和诊断优势比;绘制汇总受试者工作特征曲线(SROC)并计算曲线下面积(AUC)和Q*指数,进行异质性检验、敏感性分析和回归分析;使用Deek’s漏斗图检验文献发表偏倚。结果最终纳入11篇文献,共599例患者。Meta分析显示,各研究间存在异质性,采用随机效应模型分析,合并敏感性0.92(95%可信区间0.89~0.95),合并特异性0.73(95%可信区间0.67~0.78),合并阳性似然比4.31(95%可信区间2.39~7.77),合并阴性似然比0.08(95%可信区间0.04~0.18),合并诊断优势比53.11(95%可信区间27.39~102.97),SROC曲线下面积为0.9417,Q*指数0.8796;敏感性分析和回归分析未找到异质性来源,漏斗图未见明显发表偏倚。结论肺部超声对结缔组织病相关间质性肺疾病有较高的诊断价值,能为临床治疗提供参考。
Objective To systematically evaluate the value of lung ultrasound in the diagnosis of interstitial lung disease(ILD)related to connective tissue disease(CTD).Methods PubMed,Embase,Cochrane library,CBM,CNKI,VIP and Wanfang databases were searched during time from establishment to October 1 st 2020 to collect the articles of lung ultrasound in the diagnosis of CTD-ILD.Two researchers according to the inclusion and exclusion criteria of diagnostic tests found relevant literature and used QUADAS-2 to evaluate the quality of the literatures,and the value of lung ultrasound in the diagnosis of CTD-ILD was analyzed by RevMan 5.2,Stata 12.0 and Meta-Disc 1.4 software,the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and diagnostic odds ratio were calculated.The summarized receiver operating characteristic(SROC)curve was drawn,the area under the curve(AUC)and Q*index were calculated,the heterogeneity test,sensitivity analysis and regression analysis were conducted,and the publication bias was analyed by Deek’s test.Results Totally11 articles were included in this study,with a total of 599 patients.Meta analysis showed heterogeneity among articles and analyed by random effects model.The pooled sensitivity was 0.92(95%CI 0.89~0.95),the pooled specificity was 0.73(95%CI0.67~0.78),the pooled positive likelihood ratio was 4.31(95%CI 2.39~7.77),the pooled negative likelihood ratio was 0.08(95%CI 0.04~0.18),the pooled diagnostic odds ratio was 53.11(95%CI 27.39~102.97),the area under the SROC curve was0.94,Q*index was 0.8796.No heterogeneity was found by sensitivity analysis and regression analysis,there was no obvious publication bias.Conclusion Lung ultrasound has a high diagnostic value for CTD-ILD and can provide a reference for clinical treatment.
作者
龚海燕
唐奭麒
杨雅婷
王平
GONG Haiyan;TANG Shiqi;YANG Yating;WANG Ping(Department of Ultrasound,the Third Affiliated Hospital of Southern Medical University,Guangzhou 510630,China)
出处
《临床超声医学杂志》
CSCD
2021年第12期890-894,共5页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
结缔组织病
间质性肺疾病
META分析
Ultrasonography
Connective tissue disease
Interstitial lung disease
Meta-analysis
