摘要
胆汁淤积为临床常见的消化系统疾病,是由遗传、药物、环境等多种因素引起的胆汁合成与排出障碍的病理生理过程。胆汁在体内过度蓄积,导致肝脏细胞的结构与功能受到破坏,进而引发或加剧黄疸性肝炎、胆汁性肝纤维化甚至肝硬化等多种肝脏疾病,对患者的健康与生命造成威胁。本文着重从胆汁淤积的形成因素、生物机制等方面,对胆汁淤积的研究进展进行综述,为临床治疗胆汁淤积提供思路和参考。
Cholestasis,as a common clinical disease of digestive system,is a pathophysiological process of bile synthesis and excretion disorder caused by many factors such as heredity,drugs and environment.Excessive accumulation of the bile in the body leads to the destruction of the structure and function of liver cells,and causes or aggravates liver diseases such as jaundice hepatitis,biliary fibrosis and even cirrhosis,which pose a threat to the health and life of patients.This paper reviewed the research progress of cholestasis from its formation and biological mechanism to provide ideas and references for clinical treatment of cholestasis.
作者
卢颖
秦琳
谭道鹏
鲁艳柳
何芋岐
杨艳
张倩茹
周旭美
LU Ying;QIN Lin;TAN Dao-peng;LU Yan-liu;HE Yu-qi;YANG Yan;ZHANG Qian-ru;ZHOU Xu-mei(National Demonstration Center for Experimental(Pharmacy)Education,Key Laboratory of Basic Pharmacology,School of Pharmacy,Zunyi Medical University,Zunyi Guizhou 563000;Affiliated Hospital of Zunyi Medical University,Department of Pharmacy,Zunyi Guizhou 563000)
出处
《中南药学》
CAS
2021年第12期2603-2608,共6页
Central South Pharmacy
基金
贵州省中医药管理局中医药、民族医药科学技术研究课题(No.QZYY2017-030)
贵州省科技计划项目(黔科合支撑[2019]2953号)
黔科合平台人才[2019]5657
黔科合支撑[2020]4Y072
黔科合平台人才(No.[2017]5733-062,[2017]5733-060)。
关键词
胆汁淤积
胆汁酸通路
生物机制
cholestasis
bile acid pathway
biological mechanism
