摘要
阿尔兹海默病(AD)是导致老年人认知障碍的最常见原因,严重影响老年人生活质量的同时,造成了巨大的家庭和社会负担。AD病因及发病机制尚不完全清楚,目前认为AD由细胞外Aβ沉积及细胞内Tau蛋白过度磷酸化所导致,但针对其研发的药物未见明显疗效。病毒相关的神经炎症是近年神经系统疾病研究热点,被认为与多种神经退行性疾病有关。本文主要阐述AD与病毒感染的神经免疫机制研究进展。
Alzheimer's disease(AD)is the most common cause of cognitive impairment in the elderly,severely affecting their quality of life and causing a huge family and social burden.Etiology and pathogenesis of AD are not fully understood.It has been acknowledged that AD is caused by extracellular Aβdeposition and intracellular Tau protein hyperphosphorylation,but drugs developed for this mechanism have not shown significant efficacy.Virus-associated inflammation has been a hot topic of research in neurological disorders in recent years and is thought to be associated with many neurodegenerative diseases.This review focuses on advances in neuroimmunity mechanisms of AD and viral infections.
作者
王咏纯
孙莉(指导)
WANG Yong-Chun;SUN Li(Department of Neurology,the First Hospital of Jilin University,Changchun 130021,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2021年第23期2919-2923,2928,共6页
Chinese Journal of Immunology
基金
国家自然基金项目(82071442)。
关键词
阿尔兹海默病
病毒感染
神经免疫
Alzheimer's disease
Viral infection
Neuroimmunity
