摘要
大黄素是中药大黄、何首乌、虎杖、决明子等的主要有效成分,大量研究证实大黄素具有抗癌、抗肿瘤、抗炎、镇痛、免疫抑制、抗骨质疏松等多种药理作用,但大黄素也易引起肝肾毒性。因此,明确单体大黄素保护肝肾与肝肾毒性双向药理作用至关重要。本文通过查阅国内外相关文献,对大黄素引起肝肾毒性的机制研究进行梳理和总结,为大黄素安全用药及研究提供参考。
Emodin is the main effective component of Rhei Radix et Rhizoma,Polygoni Multiflori Radix,Polygoni Cuspidati Rhizoma et Radix,Cassia Toralinn,etc.A large number of studies have confirmed that emodin has many pharmacological effects such as anti-cancer,anti-inflammation,analgesia,immunosuppression,anti-osteoporosis and so on,but emodin is also easy to cause hepatotoxicity.Therefore,it is very important to clarify the pharmacological effects of monomer emodin on protecting liver and kidney.In this paper,the mechanism of liver and kidney toxicity induced by emodin was reviewed and summarized,providing reference for the safe use of emodin and its research.
作者
季文莹
刘效栓
肖振国
胡如英
刘欣钰
JI Wenying;LIU Xiaoshuan;XIAO Zhenguo;HU Ruying;LIU Xinyu(Gansu University of Chinese Medicine,Lanzhou Gansu 730000,China;Gansu Provincial Hospital of Chinese Medicine,Lanzhou Gansu 730050,China)
出处
《中兽医医药杂志》
CAS
2021年第6期91-94,共4页
Journal of Traditional Chinese Veterinary Medicine
基金
兰州市科技计划项目(2019-1-59)。
关键词
大黄素
肝毒性
肾毒性
氧化应激
细胞凋亡
emodin
hepatotoxicity
nephrotoxicity
oxidative stress
cell apoptosis
