摘要
目的:观察司天麦冬汤配合化疗治疗气阴两虚型Ⅲ~Ⅳ期非小细胞肺癌(NSCLC)的临床疗效。方法:选取符合纳入标准的气阴两虚证Ⅲ~Ⅳ期肺癌患者60例,随机分为两组各30例。对照组予以规范化疗;治疗组在对照组基础上口服司天麦冬汤治疗。记录两组治疗前后中医症状、卡氏功能状态评分、体重等信息以及治疗中出现的各种不良反应。21天为1个疗程,2个疗程结束后评价疗效。结果:治疗组乏力、口干咽干、自汗盗汗、失眠等中医症状以及生活质量改善情况优于对照组(P<0.05);治疗组白细胞减少、血小板减少、恶心呕吐、肾功能损伤发生率低于对照组(P<0.05)。结论:司天麦冬汤联合化疗能提高气阴两虚证肺癌的临床疗效,并在一定发程度上减轻毒副反应。
Objective:To observe the clinical efficacy of Sitian Maimendong decoction and chemotherapy on Ⅲ~Ⅳ stage NSCLC with qi-yin both deficiency syndrome.Methods:60 cases of selected patients with Ⅲ~Ⅳ stage lung cancer with qi-yin both deficiency syndrome,who met the inclusion criteria,were randomly divided into two groups,30 cases in each group.The control group was treated by standardized chemotherapy,while the treatment group was treated with oral Sitian Maimendong decoction on the basis of control group.TCM symptoms,Karnofsky performance status score,body weight and other informations as well as various adverse reactions during treatment were recorded in two groups before and after treatment.21 days as a course of treatment.The clinical efficacy was evaluated after 2 courses of treatment.Results:In the treatment group,the improvement of TCM symptoms such as fatigue,dry mouth and dry pharynx,spontaneous sweating and night sweating,insomnia,etc.as well as quality of life were better than in control group(P < 0.05).Leukopenia,thrombocytopenia,nausea-vomiting and incidence of renal dysfunction in treatment group were lower than in control group(P<0.05).Conclusion:Sitian Maimendong decoction and chemotherapy can enhance the clinical effect on lung cancer with qi-yin both deficiency syndrome,and reduce the toxic and side effects to a certain extent.
作者
柳为
张东伟
LIU Wei;ZHANG Dong-wei(Graduate School,Anhui University of Traditional Chinese Medicine,Hefei 230000,China;不详)
出处
《山西中医》
2021年第12期25-27,35,共4页
Shanxi Journal of Traditional Chinese Medicine
关键词
肺恶性肿瘤
气阴两虚
化疗
司天麦冬汤
中西医结合疗法
lung malignant tumor
qi-yin both deficiency
chemotherapy
Sitian Maimendong decoction
therapy of traditional Chinese and western medicine
