摘要
目的:探讨淋巴细胞功能相关抗原-1(LFA-1)在慢性阻塞性肺疾病(COPD)中性粒细胞性炎症反应中的表达及其临床意义。方法:选取2019年1月至2020年12月在惠州市中心人民医院就诊的COPD急性加重期(AECOPD)患者40例作为AECOPD组,COPD稳定期患者40例作为COPD稳定组,并选取健康志愿者20例作为对照组。比较各组LFA-1与中性粒细胞性炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、炎性蛋白胸腺基质淋巴细胞生成素(TSLP)、高迁移率族蛋白1(HMGB1)]及其相关性,并分析不同临床特征LFA-1水平及其独立影响因素。结果:三组LFA-1、TNF-α、IL-6、IL-8、TSLP、HMGB1水平比较:AECOPD组>COPD稳定>对照组,均有统计学意义(P<0.05)。经Pearson分析,LFA-1与TNF-α、TSLP、HMGB1不具有相关性(P>0.05),LFA-1与IL-6、IL-8呈正相关(P<0.05)。经单因素分析,吸烟、慢性阻塞性肺疾病评估测试(CAT)评分、改良版英国医学研究会呼吸问卷(m MRC)分级、慢性阻塞性肺疾病全球倡议(GOLD)分级是影响LFA-1水平的因素(P<0.05);经多元线性回归分析,吸烟、CAT评分、m MRC分级、GOLD是影响LFA-1水平的独立危险因素(P<0.05)。结论:COPD患者LFA-1与中性粒细胞性炎症因子均呈高表达,且AECOPD高于COPD稳定期患者,COPD患者LFA-1与中性粒细胞性炎症因子具有一定关联性,吸烟、CAT评分≥10分、m MRC分级≥2级、GOLD分级≥2级是导致LFA-1水平高的原因。
Objective:To investigate the expression of lymphocyte function-associated antigen-1(LFA-1)in chronic obstructive pulmonary disease(COPD)neutrophilic inflammation and its clinical significance.Methods:A total of 40 patients with acute exacerbation of COPD(AECOPD)who were in the Huizhou Central People's Hospital from January 2019 to December 2020 were made the AECOPD group,another 40 patients with stable COPD were made the stable COPD group,and 20 healthy volunteers served as a control group.Comparison was conducted among groups on LFA-1 with neutrophilic factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),inflammatory Protein thymic stromal lymphopoietin(TSLP),high mobility group protein 1(HMGB1)]and their correlations,and different clinical characteristics of LFA-1 levels and their independent influencing factors were analyzed.Results:Comparison of the levels of LFA-1,TNF-α,IL-6,IL-8,TSLP and HMGB1 in the three groups:AECOPD group>COPD stable>control group,all were statistically significant(P<0.05).According to Pearson analysis,LFA-1 is not correlated with TNF-α,TSLP,HMGB1(P>0.05),and LFA-1 is positively correlated with IL-6,IL-8(P<0.05).According to univariate analysis,smoking,chronic obstructive pulmonary disease assessment test(CAT)score,modified version of British Medical Research Council respiratory questionnaire(mMRC)classification,Global Initiative for Chronic Obstructive Lung Diseas(GOLD)classification are the factors that affect LFA-1 levels(P<0.05);After multiple linear regression analysis,smoking,CAT score,mMRC classification,and GOLD are independent risk factors that affect LFA-1 levels(P<0.05).Conclusion:COPD patients have high expression of LFA-1 and neutrophilic factors,and AECOPD is higher than that of patients with stable COPD.COPD patients LFA-1 and LFA-1 are related to neutrophilic factors.Smoking,CAT score≥10,mMRC grade≥2,GOLD grade≥2 are the reasons for the high level of LFA-1.
作者
林宇挺
李伟坚
黄培楷
LIN Yuting;LI Weijian;HUANG Peikai(Huizhou Central People's Hospital,Guangdong Huizhou 516000,China)
出处
《河北医学》
CAS
2021年第12期1974-1979,共6页
Hebei Medicine
基金
2021年度惠州市医疗卫生类科技计划项目,(编号:2021WC0106339)。
