摘要
精子形成是精子发生的最后阶段,圆形精子细胞经历了一系列的形态变化和染色质凝聚,形成了具有物种特异性的成熟精子。组蛋白–鱼精蛋白替换是精子形成过程中的重要事件。在组蛋白–鱼精蛋白替换过程中,组蛋白首先被睾丸特异性的组蛋白变体所替代,随后过渡蛋白整合到细胞核中,最后过渡蛋白被鱼精蛋白取代。组蛋白–鱼精蛋白替换缺陷可能导致无精子症、少精子症或畸精症,从而导致男性不育。本文系统总结了组蛋白–鱼精蛋白替换过程中的调控机制研究进展,以期为男性不育症的诊断和治疗提供理论基础。
Spermiogenesis is the final stage of spermatogenesis,in which round spermatids differentiate into mature sperms through a complex process including morphological changes and chromatin condensation.Histone-to-protamine transition during spermiogenesis is a critical part of this biological process.Histones are initially replaced by testis-specific histone variants,then transition proteins integrate into the nucleus,and are in turn replaced by protamine.Impaired histone-to-protamine transition may cause azoospermia,oligospermia or teratospermia,which lead to male infertility.In this review,we summarize the research progress of regulatory mechanisms of the histone-to-protamine transition,thereby providing the theoretical basis for the diagnosis and treatment of male infertility.
作者
袁露
葛婷婷
牛长敏
徐文华
郑英
Lu Yuan;Tingting Ge;Changmin Niu;Wenhua Xu;Ying Zheng(Department of Histology and Embryology,School of Medicine,Yangzhou University,Yangzhou 225009,China;Jiangsu Key Laboratory of Experimental&Translational Non-coding RNA Research,Yanghzou 225009,China)
出处
《遗传》
CAS
CSCD
北大核心
2021年第12期1121-1131,共11页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:82071696,82101674)
江苏省高校自然科学研究重大项目(编号:20KJA310002)
扬州大学研究生科研创新计划项目(编号:XKYCX20_35)资助。
关键词
精子发生
组蛋白–鱼精蛋白替换
翻译后修饰
spermiogenesis
histone-to-protamine transition
post-translational modification
