摘要
背景:衰老与缺血性卒中的发生发展有着重要关系。间充质干细胞具有自我更新、分化及分泌功能,可以对缺血性卒中起着一定的治疗作用。目的:综述衰老与缺血性卒中的关系以及间充质干细胞治疗衰老相关缺血性卒中的作用机制。方法:检索万方、中国知网、PubMed和Web of Science数据库中2006-2021年期间衰老与缺血性卒中的关系及间充质干细胞治疗缺血性脑卒中的文献,以“衰老、间充质干细胞、缺血性脑卒中”为中文检索词,以“aging,mesenchymal stem cells(MSCs),ischemic stroke”为英文检索词进行检索,共纳入58篇文献进行分析。结果与结论:①间充质干细胞具有分化、可分泌营养因子和囊泡的作用,可以用于衰老相关缺血性卒中的治疗;②衰老的病理过程包括衰老细胞的积累激活衰老相关的炎症因子分泌,恶化细胞生存的微环境,炎症反应使衰老后神经血管单元损伤加重,氧化应激引起细胞内线粒体结构破坏和功能障碍,端粒的缩短以及遗传物质的改变等,这些因素与衰老密切相关且影响动脉粥样硬化的稳定性,与缺血性卒中的发生发展密切相关;③间充质干细胞治疗衰老相关缺血性脑卒中的作用机制主要包括:清除衰老细胞阻断炎症介质通路的损害,抑制促炎因子的表达减轻炎症反应,神经生成促进神经功能修复,增加脑血流量促进血管新生,分泌外泌体具有间充质干细胞的类似功能,可为今后间充质干细胞治疗缺血性脑卒中提供相关参考。④间充质干细胞移植虽然可以起到治疗缺血性脑卒中的作用,但是其移植后的迁移率及分布、分化细胞种类及分布、存活率、增殖情况、脑立体局部注射还是动静脉注射等问题需要进一步解决,探索更有效的细胞移植策略是关键因素,未来希望其能够通过联合抗衰老药物预防动脉粥样硬化,预防脑卒中。
BACKGROUND:Aging has an important relationship with the occurrence and development of ischemic stroke.Mesenchymal stem cells have the functions of self-renewal,differentiation and secretion,and may play a certain role in the treatment of ischemic stroke.OBJECTIVE:To review the relationship between aging and ischemic stroke and the mechanism of action of mesenchymal stem cells in the treatment of aging-related ischemic stroke.METHODS:The articles on the relationship between aging and ischemic stroke and mesenchymal stem cells for treatment of ischemic stroke published from 2006 to 2021 were searched in Wanfang,CNKI,PubMed,and Web of Science.The key words were“aging,mesenchymal stem cells(MSCs),ischemic stroke”in Chinese and English.A total of 58 articles were included for analysis.RESULTS AND CONCLUSION:(1)Mesenchymal stem cells can differentiate and secrete nutritional factors and vesicles and can be used for the treatment of aging-related ischemic stroke.(2)The pathological process of aging includes the accumulation of senescent cells to activate the secretion of inflammatory factors related to aging,which deteriorates the microenvironment of cell survival.The inflammatory response makes neurovascular unit damage after aging even worse.Oxidative stress causes the destruction of intracellular mitochondrial structure and dysfunction.The shortening of grains and changes in genetic material are closely related to aging and affect the stability of atherosclerosis,and are closely related to the occurrence and development of ischemic stroke.(3)The action mechanisms of mesenchymal stem cells in the treatment of aging-related ischemic stroke mainly include:removing senescent cells and blocking the damage of inflammatory mediator pathways,inhibiting the expression of pro-inflammatory factors,reducing inflammation,neurogenesis,promoting nerve function repair,increasing cerebral blood flow,promoting angiogenesis,secreting exosomes and having similar function of mesenchymal stem cells,which can provide relevant reference
作者
陈娜
王晓含
张运克
Chen Na;Wang Xiaohan;Zhang Yunke(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,Henan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2022年第24期3914-3920,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(81974564),项目负责人:张运克。
关键词
细胞衰老
间充质干细胞
缺血性脑卒中
血管新生
神经生成
炎症反应
外泌体
端粒
cell senescence
mesenchymal stem cells
ischemic stroke
angiogenesis
neurogenesis
inflammatory response
exosomes
telomere
