摘要
目的探究观察归逍方加减联合人工周期对卵巢早衰闭经(肾虚肝郁证)的治疗效果。方法将2017年8月至2019年1月安阳市人民医院收治的96例卵巢早衰闭经(肾虚肝郁证)病人作为研究对象,采用随机数字表法分为对照组47例和观察组49例。观察组病人采用归逍方加减联合人工周期进行治疗,对照组病人进行人工周期治疗。对比两组病人治疗前后的症状积分、治疗前后的性激素水平、治疗前后卵巢体积与窦卵泡数、临床疗效分布及总有效率,不良反应发生情况。结果两组病人治疗前症状积分均相近(P>0.05),且治疗后两组症状积分均下降[对照组:(15.96±3.01)分比(7.97±1.57)分,(8.86±1.86)分比(5.97±1.17)分,(24.82±4.43)分比(13.94±2.29)分;观察组:(16.18±3.15)分比(5.51±1.05)分,(8.95±1.58)分比(4.15±0.88)分,(25.13±4.52)分比(9.66±1.87)分](P<0.05),观察组均低于对照组(P<0.05);治疗后两组病人的黄体生成素(LH)、卵泡刺激素(FSH)水平比治疗前均降低[对照组:(47.72±9.51)IU/L比(28.42±5.43)IU/L,(66.23±13.22)IU/L比(36.91±7.13)IU/L;观察组:(45.53±9.81)IU/L比(21.51±4.12)IU/L,(64.11±13.12)IU/L比(27.02±5.31)IU/L](P<0.05),同时观察组均低于对照组(P<0.05),两组病人的雌激素(E_(2))水平比治疗前均升高[对照组:(44.30±8.40)ng/L比(77.50±12.37)ng/L;观察组:(46.30±9.39)ng/L比(83.36±13.25)ng/L](P<0.05),同时观察组均高于对照;治疗后两组病人的卵巢体积比治疗前均变大、窦卵泡数比治疗前均增多[对照组:(9.02±1.23)cm^(3)比(11.03±2.14)cm^(3),(2.74±0.46)个比(3.41±0.69)个;观察组:(9.11±1.82)cm^(3)比(13.12±2.59)cm^(3),(2.87±0.53)个比(5.68±1.12)个](P<0.05),且观察组各指标变化幅度均大于对照组(P<0.05);观察组病人治疗效果等级分布与对照组比较差异有统计学意义(P<0.05),且观察组的治疗总有效率是85.71%,比对照组的61.70%高(P<0.05);观察组不良反应发生率为4.44%与对照组的4.26%相近(P>0.
Objective To investigate the therapeutic effect of Guixiaofang addition and subtraction combined with artificial cycle on ovarian premature aging obstruction(kidney deficiency and liver stagnation syndrome).Methods A total of 96 patients with ovarian premature aging obstruction(kidney deficiency and liver stagnation syndrome)admitted to Anyang People's Hospital from August 2017 to January 2019 were randomly divided into control group(47 cases)and 49 observation group(49 cases)by a random digital table.Patients in the observation group were treated with Guixiaofang plus artificial reduction,and the control group was treated with artificial cycle.The symptom scores before and after treatment,the levels of sex hormones before and after treatment,ovarian volume and antral follicle number before and after treatment,the clinical efficacy distributions and total effective rates,the incidence of adverse reactions were compared between the two groups.Results The symptom scores of the two groups were similar before treatment(P>0.05),and the symptom scores of the two groups were decreased after treatment[control group:(15.96±3.01)scores vs.(7.97±1.57)scores,(8.86±1.86)scores vs.(5.97±1.17)scores,(24.82±4.43)scores vs.(13.94±2.29)scores;observation group:(16.18±3.15)scores vs.(5.51±1.05)scores,(8.95±1.58)scores vs.(4.15±0.88)scores,(25.13±4.52)scores vs.(9.66±1.87)scores](P<0.05),and those in the observation group were lower than those in the control group(P<0.05),The levels of luteinizing hormone(LH),follicle stimulating hormone(FSH)in the two groups were lower than those before treatment[control group:(47.72±9.51)IU/L vs.(28.42±5.43)IU/L,(66.23±13.22)IU/L vs.(36.91±7.13)IU/L;observation group:(45.53±9.81)IU/L vs.(21.51±4.12)IU/L,(64.11±13.12)IU/L vs.(27.02±5.31)IU/L](P<0.05),and those in the observation group was lower than those in the control group(P<0.05).The estradiol(E_(2))levels of the two groups were higher than those before treatment[control group:(44.30±8.40)ng/L vs.(77.50±12.37)ng/L;observat
作者
张艳
ZHANG Yan(Department of Traditional Chinese Medicine,Anyang People's Hospital,Anyang,Henan 455000,China)
出处
《安徽医药》
CAS
2022年第1期192-196,共5页
Anhui Medical and Pharmaceutical Journal
关键词
原发性卵巢功能不全
黄体生成素
卵泡刺激素
归逍方
人工周期疗法
卵巢早衰
闭经
肾虚肝郁证
Primary ovarian insufficiency
Luteinizing hormone
Follicle stimulating hormone
Guixiaofang
Artificial cycle therapy
Premature ovarian failure
Amenorrhea
Kidney deficiency liver stagnation syndrome
