摘要
目的:观察复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化患者的效果。方法:选取105例酒精性肝硬化患者作为研究对象,按照随机数字表法将其分为对照组(n=52)与观察组(n=53)。对照组采用注射用还原型谷胱甘肽治疗,观察组在对照组的基础上采用复方甘草酸苷片治疗,比较两组临床疗效、治疗前后疾病相关指标[血清胰岛素样生长因子1(IGF-1)、透明质酸(HA)、丙氨酸氨基转氨酶(ALT)、血清骨钙素(BGP)、总胆红素(TBiL)]水平和不良反应发生率。结果:观察组治疗总有效率为96.23%,明显高于对照组的82.69%,差异有统计学意义(P<0.05);治疗后,观察组IGF-1和BGP水平均高于对照组,HA、ALT和TBiL水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化患者可提高治疗总有效率,改善疾病相关指标水平,其效果优于单纯还原型谷胱甘肽治疗。
Objective:To observe effects of compound glycyrrhizin combined with reduced glutathione in treatment of patients with alcoholic liver cirrhosis.Methods:105 patients with alcoholic liver cirrhosis were selected as the research objects,and were divided into control group(n=52)and observation group(n=53)according to the random number table method.The control group was treated with reduced glutathione for injection,while the observation group was treated with compound glycyrrhizin tablets on the basis of that of the control group.The clinical efficacy,the disease-related indicator levels[serum insulin-like growth factor 1(IGF-1),hyaluronic acid(HA),alanine aminotransferase(ALT),serum osteocalcin(BGP),total bilirubin(TBiL)]and the incidence of adverse reactions before and after treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.23%,which was significantly higher than 82.69%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IGF-1 and BGP in the observation group were higher than those in the control group;the levels of HA,ALT and TBiL were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:Compound glycyrrhizin combined with reduced glutathione in the treatment of the patients with alcoholic liver cirrhosis can increase the total effective rate of treatment and improve the levels of disease-related indicators.Moreover,it is superior to single reduced glutathione treatment.
作者
刘瑶
LIU Yao(People’s Hospital of Yubei District of Chongqing City,Yubei 401120 Chongqing,China)
出处
《中国民康医学》
2021年第22期12-14,共3页
Medical Journal of Chinese People’s Health
关键词
复方甘草酸苷
还原型谷胱甘肽
肝功能
酒精性肝硬化
Compound glycyrrhizin
Reduced glutathione
Liver function
Alcoholic liver cirrhosis
