摘要
目的探讨健康人群血清同型半胱氨酸(homocysteine,Hcy)水平的群体特征和影响因素,为高同型半胱氨酸血症(HHcy)的健康管理提供参考依据。方法选取某物业公司来北京市化工职业病防治院进行健康体检的1037例体检者作为研究对象,收集一般资料,同时进行血清Hcy水平及生化、甲功代谢指标的检测,根据Hcy水平分为正常组(<15mmol/L)712例和HHcy(≥15mmol/L)组325例,比较两组人群在一般资料和代谢指标间的差异,采用Logistic回归分析Hcy水平的影响因素。结果1037例研究对象年龄20~66岁,平均年龄38.8±9.4岁,HHcy检出率为31.34%;与正常组相比,HHcy组的男性比例、高血压检出率、颈动脉斑块检出率、血清肌酐(CR)、尿酸(UA)较高,高密度脂蛋白(HDL-C)水平较低,组间差异具有统计学意义(均P<0.05),二元Logistic回归显示,性别、血压、颈动脉斑块、CR和HDL-C水平是Hcy水平的影响因素。结论健康体检人群Hcy水平与多种因素相关,受男性、高血压、颈动脉斑块、CR以及低HDL-C水平的影响较大,尽早有效控制这些因素是防治HHcy的关键。
Objective To investigate the characteristics and influencing factors of serum homocysteine(Hcy)level in healthy population,and to provide a reference for the health guidance of high homocysteinemia(HHcy)in healthy people.Methods We selected 1037 cases of medical examination from a property company who visited Chemical Prevention and Control of Occupational Diseases in Beijing Institute for physical examination as the research objects.The general information was collected,while at the same time serum Hcy levels and biochemical,metabolic index were detected.We divided subjects into two groups according to the level of Hcy(<15 tendency/L)with 712 cases and HHcy 15 tendency(p/L)group with 325 cases.We compared two groups for the general information and metabolic index,and used logistic regression analysis for the influence factors of Hcy levels.Results 1037 subjects ranged in age from 20 to 66 years old,with an average age of 38.8±9.4 years old.The HHcy detection rate was 31.34%.When compared with the normal group,the HHcy group showed a higher male ratio,detection rate of hypertension,carotid artery plaque detection rate and creatinine,uric acid,while a lower level of high-density lipoprotein(HDL-C)(all P<0.05),Binary logistic regression showed that sex,blood pressure,carotid plaques,crertinine and HDL-C were influence factors of Hcy levels.Conclusion The level of Hcy in healthy people is related to a variety of factors,among which male,hypertension,carotid plaque,high crertinine level and low HDL-C level are the risk factors for increased Hcy.Effective control of these factors as early as possible is the key to the prevention and treatment of HHcy.
作者
何俊秋
王会宁
张曼
HE Junqiu;WANG Huining;ZHANG Man(The Beijing Prevention and Treatment Hospital of Occupational Disease for Chemical Industry Beijing/Beijing Instituteof Occupational Disease Prevention and Treatment,Beijing 100093,China;Department of Clinical Laboratory,Beijing Shijitan Hospital,Capital Medical University, Beijing 100038,China)
出处
《标记免疫分析与临床》
CAS
2021年第11期1844-1847,共4页
Labeled Immunoassays and Clinical Medicine
