摘要
目的探讨枸橼酸咖啡因在早产儿中的临床应用效果及对患儿肺功能的影响。方法选取2019年7月至2020年12月赣州市南康区第一人民医院的60例早产儿患者作为研究对象,采用随机数字表法将其分为对照组与观察组,各30例。对照组采用氨茶碱治疗,观察组采用枸橼酸咖啡因治疗。比较两组患者治疗前后的肺功能指标、呼吸机辅助通气时间、严重早产儿呼吸暂停(AOP)、支气管肺发育不良(BPD)发生率及疗效。结果治疗前,两组患儿的肺功能指标比较,差异无统计学意义(P>0.05)。治疗后,观察组患儿的呼吸频率、每分钟通气量、潮气量均高于对照组,差异有统计学意义(P<0.05)。观察组患儿的呼吸机辅助通气时间短于对照组,严重AOP发生率、BPD发生率均低于对照组,差异有统计学意义(P<0.05)。观察组患儿的治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因治疗在早产儿中的效果良好,可改善肺功能,建议优先选择。
Objective To explore the clinical application effect of Caffeine Citrate in premature infants and its influence on lung function of infants.Methods From July 2019 to December 2020,60 patients with premature infants from the First People′s Hospital of Nankang District of Ganzhou City were selected as the research subjects.They were divided into the control group and the observation group using the random number table method,with 30 cases in each group.The control group was treated with Aminophylline,and the observation group was treated with Caffeine Citrate.The pulmonary function indexes before and after treatment,ventilator-assisted ventilation time,the incidence of severe apnea of prematurity(AOP),bronchopulmonary dysplasia(BPD)and curative effect were compared between the two groups.Results Before treatment,there were no statistically significant differences in the pulmonary function indexes between the two groups(P>0.05).After treatment,the respiratory frequency,ventilation per minute and tidal volume of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The ventilator-assisted ventilation time of children in the observation group was shorter than that of the control group,and the incidence rates of severe AOP and BPD of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total effectiveness rate of treatment for children in the observation group was 93.33%,which was higher than that of the control group accounting for 73.33%,and the difference was statistically significant(P<0.05).Conclusion Caffeine Citrate therapy is effective in premature infants and can improve pulmonary function,it is recommended to choose in preference.
作者
赖日斌
李秀华
刘丽美
LAI Ri-bin;LI Xiu-hua;LIU Li-mei(Department of Neonatology,the First People′s Hospital of Nankang District of Ganzhou City,Jiangxi Province,Ganzhou 341400,China)
出处
《中国当代医药》
CAS
2021年第35期115-117,共3页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2020ZSF 469)。
关键词
枸橼酸咖啡因
早产儿
肺功能
早产儿呼吸暂停
支气管肺发育不良
治疗有效率
Caffeine Citrate
Premature infants
Lung function
Apnea of prematurity infants
Bronchopulmonary dysplasia
Effective treatment rate
