摘要
目的探讨胰胆炎合剂联合注射用生长抑素治疗急性胰腺炎的临床疗效。方法选取2019年4月—2021年6月在南阳市中心医院就诊的83例急性胰腺炎患者,根据随机数字表法将所有患者分为对照组(40例)和治疗组(41例)。对照组静脉滴注注射用生长抑素,3 mg加入50 mL生理盐水中,静脉持续泵注,速度为250μg/h,1次/d。治疗组在对照组基础上口服胰胆炎合剂,1袋/次,2次/d。两组患者连续治疗7 d。观察两组患者临床疗效,比较两组症状消失时间,血清脂肪酶、淀粉酶、高迁移率族蛋白B1(HMGB1)、二胺氧化酶(DAO)、白细胞介素-35(IL-35)水平。结果治疗后,治疗组总有效率为92.68%,对照组总有效率为75.00%,组间有明显差异(P<0.05)。治疗后,治疗组的高热、腹痛、腹胀、恶心、呕吐消失时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组的脂肪酶、淀粉酶水平显著降低(P<0.05),且以治疗组脂肪酶、淀粉酶水平降低更明显(P<0.05)。治疗后,两组的HMGB1、DAO、IL-35水平明显减少(P<0.05);且治疗组治疗后的HMGB1、DAO、IL-35水平低于对照组,差异有统计学意义(P<0.05)。结论胰胆炎合剂联合注射用生长抑素治疗急性胰腺炎的疗效确切,可改善临床症状,促进胰酶分泌,缓解炎症反应程度,药物安全性良好。
Objective To investigate the clinical efficacy of Yidanyan Mixture combined with Somatostatin for injection in treatment of acute pancreatitis. Methods Patients(83 cases) with acute pancreatitis in Nanyang Central Hospital from April 2019 to June 2021 were randomly divided into the control group(40 cases) and the treatment group(41 cases). Patients in the control group were iv administered with Somatostatin for injection, 3 mg added into normal saline 50 mL, continuous intravenous pumping, speed 250 μg/h,once daily. Patients in the treatment group were po administered with Yidanyan Mixture on the basis of the control group, 1 bag/time,three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of symptoms and the serum levels of lipase, amylase, HMGB1, DAO, and IL-35 in two groups were compared.Results After treatment, the total effective rate of the treatment group was 92.68%, the total effective rate of the control group was 75.00%, and there was a significant difference between two groups(P < 0.05). After treatment, the disappearance time of high fever,abdominal pain, abdominal distension, nausea, and vomiting in the treatment group was shorter than that in the control group(P <0.05). After treatment, the levels of lipase and amylase in two groups were significantly decreased(P < 0.05), and the levels of lipase and amylase in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the levels of HMGB1, DAO, and IL-35 in two groups were significantly decreased(P < 0.05). The levels of HMGB1, DAO, and IL-35 in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Yidanyan Mixture combined with Somatostatin for injection is effective in treatment of acute pancreatitis, which can improve the efficiency of clinical symptoms,promote the secretion of pancreatin, and alleviate the degree of inflammation, with good safety.
作者
李长力
郑喜胜
贾明雅
董照刚
马静
魏超
荀莉
杨潇
LI Chang-li;ZHENG Xi-sheng;JIA Ming-ya;DONG Zhao-gang;MA Jing;WEI Chao;XUN Li;YANG Xiao(Department of Critical Medicine,Nanyang Central Hospital,Nanyang 473000,China;Medical Record Statistics Department,Nanyang Central Hospital,Nanyang 473000,China;Department of Traditional Chinese Medicine,Henan(Zhengzhou)Zhonghui Cardiovascular Hospital,Zhengzhou 450000,China)
出处
《现代药物与临床》
CAS
2021年第11期2318-2322,共5页
Drugs & Clinic
基金
河南省医学科技攻关计划联合共建项目(LHGJ20191164)。
关键词
胰胆炎合剂
注射用生长抑素
急性胰腺炎
症状消失时间
脂肪酶
炎症反应
Yidanyan Mixture
Somatostatin for injection
acute pancreatitis
disappearance time of symptom
trypsin
inflammatory response
