摘要
目的:观察脐灸疗法对痰湿体质的调控作用及对肠道菌群的影响,探讨脐灸改善痰湿体质的作用机制。方法:将60例痰湿体质受试者随机分为观察组和对照组,每组30例。对照组予饮食及运动等中医养生指导;观察组在对照组基础上予脐灸疗法,每次7壮,每周2次,两组均干预8周。分别于干预前后记录两组受试者痰湿体质相关指标[痰湿体质转化分、体质量、体质量指数(BMI)、腰围、臀围、心率、血压],采用16S rDNA测序技术分析两组受试者肠道菌群变化。结果:干预后,观察组受试者痰湿体质转化分、体质量、BMI、腰围、臀围较干预前降低(P<0.001,P<0.01,P<0.05),对照组受试者痰湿体质转化分、腰围较干预前降低(P<0.001,P<0.05);观察组痰湿体质转化分及腰围均低于对照组(P<0.001,P<0.05)。干预后,观察组霍氏真杆菌属相对丰度增加(P<0.01),对照组布劳特氏菌属相对丰度减少(P<0.05)。结论:脐灸可能通过上调霍氏真杆菌属相对丰度重塑肠道菌群,从而调控痰湿体质。
Objective To observe the effect of umbilical moxibustion on phlegm damp constitution and intestinal flora,and explore the mechanism of umbilical moxibustion in improving phlegm damp constitution.Methods A total of 60 subjects with phlegm damp constitution were randomly divided into an observation group and a control group,30 cases in each group.The control group was given TCM health guidance,such as diet and exercise;on the basis of the control group,umbilical moxibustion was applied in the observation group,7 moxa cones each time,2 times a week for 8 weeks.Before and after intervention,the indexes(transformation score of phlegm damp constitution,body mass,body mass index[BMI],waist circumference,hip circumference,heart rate and blood pressure)related to phlegm damp constitution were recorded in the two groups.The intestinal flora was detected with 16S rDNA sequencing technology in the two groups.Results After intervention,the transformation score of phlegm damp constitution,body mass,BMI,waist circumference and hip circumference were decreased compared before intervention in the observation group(P<0.001,P<0.01,P<0.05),the transformation score of phlegm damp constitution and waist circumference were decreased compared before intervention in the control group(P<0.001,P<0.05);the transformation score of phlegm damp constitution and waist circumference in the observation group were lower than the control group(P<0.001,P<0.05).After intervention,the relative abundance of Eubacterium hallii in the observation group was increased(P<0.01),the relative abundance of Blautia in the control group was decreased(P<0.05).Conclusion Umbilical moxibustion may reshape the intestinal flora by up-regulating the relative abundance of Eubacterium hallii,thus improving phlegm damp constitution.
作者
景彩
肖宁
于慧娟
张昌云
张昕
谭奇纹
JING Cai;XIAO Ning;YU Hui-juan;ZHANG Chang-yun;ZHANG Xin;TAN Qi-wen(College of Acunpuncture-Moxibustion and Tuina,Shandong University of TCM,Jinan 250355,China;Center for Disease Prevention,Affiliated Hospital of Shandong University of TCM)
出处
《中国针灸》
CAS
CSCD
北大核心
2021年第12期1360-1364,1382,共6页
Chinese Acupuncture & Moxibustion
基金
山东中医药大学治未病科研创新团队项目:220318。
关键词
痰湿体质
脐灸
肠道菌群
phlegm damp constitution
umbilical moxibustion
intestinal flora
