摘要
研究一种抗敏修护组合物对敏感性皮肤的舒缓修护功效。采用LPS诱导RAW264.7小鼠巨噬细胞释放TNF-a实验及红细胞溶血实验对其抗炎作用、眼刺激性进行评估。采用人体临床测试,基于研究者评估、仪器测量以及受试者自评等三个维度对其进行测试评价。结果显示,该组合物质量分数在20%及以内,对RAW264.7小鼠巨噬细胞的活力无显著影响,对LPS诱导下的TNF-a的生成具有明显的抑制作用;红细胞溶血实验显示为无刺激性;使用该组合物4周后,受试者皮肤红斑、脱屑、光滑度以及粗糙度较使用前皆有改善,差异有统计学意义(P<0.05)。综合受试者使用前后皮肤角质层含水量、TEWL值、红区面积变化、乳酸刺激性以及对刺痛、瘙痒、紧绷和灼热等皮肤问题的缓解率等,表明该组合物具有显著的舒缓和修护功能,差异有统计学意义(P<0.05)。4周的试验期间未出现任何皮肤不良反应,表明其对敏感性皮肤人群具有良好的安全性,适用于敏感性皮肤人群。
The soothing and repair functions of“Franicshield”on sensitive skin were studied.The anti-allergy&repair composition“Franicshield”was composed of ceramide,squalane and other skin lipid components to repair the skin barrier function;sodium hyaluronate and aloe leaf water were used to replenish water and moisturize the skin;natural active extracts such as Centella asiatica,Polygonum hydropiper and Inonotus obliquus were used to reduce skin inflammation and soothe skin.The anti-inflammatory effect and eye irritation were evaluated by TNF-a release induced by LPS from mouse macrophages(RAW264.7)and erythrocyte hemolysis test.Human clinical test was used for evaluation based on three dimensions:researcher evaluation,instrument measurement and subject self-assessment.The results showed that it had no significant effect on the activity of RAW264.7 mouse macrophages,and significantly inhibited the production of TNF-a inflammatory factor induced by LPS when the mass fraction of“Franicshield”was within 20%.The erythrocyte hemolysis test showed no irritation.After using“Franicshield”for 4 weeks,the subjects’skin erythema,scaling,smoothness and roughness were improved,and the difference was statistically significant(P<0.05).The water content of stratum corneum,TEWL value,red area change,lactic acid irritation and the relief rate of skin problems such as tingling,itching,tension and burning before and after use showed that“Franicshield”had good soothing and repair functions,and the difference was statistically significant(P<0.05).No adverse skin reactions occurred during the 4-week test,indicating that it had good safety and was suitable for people with sensitive skin.
作者
陈庆生
孟潇
刘婷
李楚忠
周兆芳
龚盛昭
Chen Qingsheng;Meng Xiao;Liu Ting;Li Chuzhong;Zhou Zhaofang;Gong Shengzhao(Guangzhou Uniasia Cosmetic Technology Co.Ltd.,Guangzhou,Guangdong 510663,China;Guangdong Industry Technical College,Guangzhou,Guangdong 510300,China)
出处
《日用化学工业》
CAS
北大核心
2021年第12期1221-1227,共7页
China Surfactant Detergent & Cosmetics
