摘要
目的探究缺血性脑卒中患者采用奥拉西坦联合丹红注射液治疗的效果,及对患者B淋巴细胞瘤-2(BCL-2)、BCL-2相关X蛋白(BAX)、天冬氨酸特异性半胱氨酸蛋白酶-3(Caspase-3)蛋白表达水平的影响。方法选取黄河三门峡医院2015年10月至2018年10月收治的100例缺血性脑卒中患者,通过抽签法将患者随机分为对照组及观察组,每组各50例,对照组在常规治疗的基础上联合奥拉西坦治疗,观察组在对照组的基础上联合丹红注射液治疗,分析两组治疗效果、炎症因子水平以及蛋白表达水平的差异。结果研究期间无病例脱落情况发生,观察组治疗总有效率为96.00%(48/50),明显高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗前两组患者白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05),治疗后两组患者的炎症因子水平均得到显著改善,且观察组各炎症因子水平显著低于对照组(P<0.05);治疗前两组患者BCL-2、BAX、Caspase-3蛋白表达水平比较,差异无统计学意义(P>0.05),治疗后两组患者各蛋白表达水平均得到显著改善,且观察组BCL-2水平明显高于对照组、BAX及Caspase-3水平明显低于对照组(P<0.05)。结论联合应用奥拉西坦和丹红注射液的治疗方案能够有效提高缺血性脑卒中的临床疗效,缓解机体炎症反应,这可能与其对BCL-2、BAX、Caspase-3蛋白表达水平的调节作用有密切关系。
Objective To explore the effect of oxiracetam combined with Danhong Injection in the treatment of patients with ischemic stroke and its effect on the levels of B-cell lymphoma-2(BCL-2),BCL-2-associated X protein(BAX)and aspartate-specific cysteine protease-3(Caspase-3)protein.Methods A total of 100 patients with ischemic stroke admitted to Yellow River Sanmenxia Hospital from October 2015 to October 2018 were selected.The above patients were randomly divided into the control group and the observation group by lottery,with 50 cases in each group.The control group received conventional treatment combined with oxiracetam,and the observation group was treated with Danhong Injection on the basis of the control group.The differences in the treatment effect,inflammatory factor levels and protein expression levels between the two groups were analyzed.Results During the study period,no cases dropped out of the study.The total effective rate of treatment in the observation group(96.00%,48/50)was significantly higher than that in the control group(80.00%,40/50),with statistically significant difference(P<0.05).There were no significant differences in the levels of Interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)between the two groups before treatment(P>0.05).After treatment,the levels of inflammatory factors in the two groups were significantly improved and the level of each inflammatory factor in the observation group was significantly lower than that in the control group(P<0.05).There were no significant differences in the levels of BCL-2,BAX,and Caspase-3 proteins between the two groups before treatment(P>0.05).After treatment,the protein expression levels of the two groups were significantly improved,and BCL-2 in the observation group was significantly higher than that in the control group,and BAX and Caspase-3 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Oxiracetam combined with Danhong Injection can effectively improve the clinical efficacy in i
作者
刘洁
任利霞
LIU Jie;REN Lixia(Department of Infection Management,Yellow River Sanmenxia Hospital,He'nan,Sanmenxia 472000,China;Department of Pharmacy,Yellow River Sanmenxia Hospital,He'nan,Sanmenxia 472000,China)
出处
《中国医药科学》
2021年第21期123-126,共4页
China Medicine And Pharmacy
