摘要
目的探究血清基质金属蛋白酶-3(MMP-3)、白细胞介素-18(IL-18)水平对胫骨高位截骨(HTO)治疗膝骨关节炎(KOA)的疗效评估价值及其与血清前列腺素E2(PGE2)的相关性。方法选取2019年1月至2020年1月新里程安钢总医院收治接受HTO手术治疗的KOA患者120例,对所有患者治疗前后MMP-3、IL-18、PGE-2水平进行比较。运用多因素Logistic回归分析影响HTO治疗KOA疗效的影响因素。分析血清MMP-3、IL-18水平对HTO治疗KOA的疗效评估价值。采用Pearson相关分析法对血清MMP-3、IL-18与血清PGE-2的相关性进行分析。结果KOA患者经HTO治疗后血清MMP-3、IL-18、PGE-2水平与治疗前相比明显下降,差异有统计学意义(P<0.05)。治疗后1年与治疗后相比,差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,血清MMP-3、IL-18水平升高是影响HTO治疗KOA治疗效果的独立危险因素(P<0.05)。血清MMP-3、IL-18联合指标评估HTO治疗KOA治疗效果确切的特异性(89.87%)、灵敏度(87.91%)、AUC(0.915)均显著高于单一指标(P<0.05)。Pearson相关分析结果显示,血清MMP-3、IL-18与血清PGE-2均呈正相关(r=0.714,r=0.653)(P<0.05)。120例HTO治疗KOA患者,经1年随访,失访3例。影像学复查结果显示,175例患者均达截骨处骨性愈合,FTA角度为168°~172°,矫正角度8°~18°,平均(12.05±3.26)°。结论血清MMP-3、IL-18水平对HTO治疗KOA的疗效评估价值较高,联合指标的评价准确性优于单一指标,且血清MMP-3、IL-18水平与血清PGE-2均呈正相关。
Objective To explore the value of serum matrix metalloproteinase-3(MMP-3)and interleukin-18(IL-18)levels in the treatment of Knee osteoarthritis(KOA)by High Tibial osteotomy(HTO)and their correlation with Prostaglandin E2(PGE2).Methods 120 KOA patients admitted to our hospital for HTO surgery from January 2019 to January 2020 were selected,and the levels of serum MMP-3,IL-18 and PGE-2 were compared before and after treatment.Multivariate Logistic regression was used to analyze the factors influencing the efficacy of HTO in the treatment of KOA.The Area under curve(AUC)of Receiver Operating Characteristics(ROC)was used to analyze the efficacy evaluation value of serum MMP-3 and IL-18 levels in the HTO treatment of KOA.Pearson correlation analysis was used to analyze the correlation between serum MMP-3 and IL-18 and serum PGE-2.Results The serum levels of MMP-3,IL-18 and PGE-2 in KOA patients after HTO treatment were significantly lower than those before treatment(P<0.05).There was no significant difference between 1 year after treatment and after treatment(P>0.05).The results of multivariate Logistic regression analysis showed that the elevated serum MMP-3 and IL-18 levels were independent risk factors affecting the therapeutic effect of HTO treatment for KOA(P<0.05).The specificity(89.87%),sensitivity(87.91%)and AUC(0.915)of the combined indicators of serum MMP-3 and IL-18 in evaluating the therapeutic effect of HTO on KOA were significantly higher than those of single indicator(P<0.05).The results of Pearson correlation analysis showed that serum MMP-3 and IL-18 were positively correlated with serum PGE-2(r=0.714,r=0.653)(P≤0.05).120 patients with KOA treated with HTO were followed up for1 year and 3 patients were lost to follow-up.The imaging review results showed that 127 patients achieved osseous union at the osteotomy site,with FTA angle of 168°~172°and the correction angle was 8°~18°,with an average of(12.05±3.26)°.Conclusion Serum MMP-3 and IL-18 levels are of high value in evaluating the efficacy
作者
王俊江
王红建
宋晓磊
丁俊青
韩井民
袁伟杰
桑振飞
张宾
WANG Junjiang;WANG Hongjian;SONG Xiaolei;DING Junqing;HAN Jingmin;Yuan Weijie;SANG Zhenfei;ZHANG Bin(Department of Orthopedics,Anyang General Hospital,Anyang,Henan,China,455004;Department of Laboratory Medicine,Anyang General Hospital,Anyang,Henan,China,455004)
出处
《分子诊断与治疗杂志》
2021年第11期1866-1870,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划项目(2018072139)。
