摘要
报道了一种简单且温和的铜催化萘-1-胺与亚磺酸钠和亚磺酸锂的磺酰化反应.在反应以碘作为氧化剂,在比较温和的反应条件下,可以高选择性地实现萘环C(4)的磺酰化反应,并且以中等至较高产率生成了各种砜类衍生物.
A simple and mild copper-catalyzed sulfonylation of naphthalen-1-amine with sodium and lithium sulfinates is reported.In the presence of iodine as oxidant a highly site-selective C—H functionalization at the C(4)position took place.The reaction proceeded readily mild conditions and various sulfones were synthesized in moderate to high yields.
作者
周翔
余茹鉴
王金涛
廖向文
熊艳师
Zhou Xiang;Yu Rujian;Wang Jiantao;Liao Xiangwen;Xiong Yanshi(Jiangxi Provincial Key Laboratory of Drug Design and Evaluation,School of Pharmacy,Jiangxi Science&Technology Normal University,Nanchang 330013)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第11期4370-4377,共8页
Chinese Journal of Organic Chemistry
基金
江西省教育厅青年项目(Nos.GJJ190619,GJJ201143)
江西科技师范大学博士科研启动基金(No.2019BSQD016)资助项目.
关键词
铜催化
磺酰化
远程C—H官能团化
copper-catalyzed
sulfonylation
remote C—H functionalization
