摘要
氢化苯并呋喃骨架广泛存在于生物活性分子、天然产物和药物分子中,过渡金属催化的O-环己二烯酮型1,6-烯炔经分子内或分子间C—H键官能团化/环化串联反应是构建这类骨架较为经济、有效的方法.总结了过渡金属催化O-环己二烯酮型1,6-烯炔经C—H键官能团化/环化串联反应合成氢化苯并呋喃类化合物反应的研究进展,主要介绍了各类过渡金属催化的反应类型、反应机理和手性控制中配体的选择,并对该领域所面临的挑战和发展前景进行了展望与探讨.
Hydrobenzofurans are abundant in bioactive molecules,natural products and drug molecules.Transition-metalcatalyzed intramolecular or intermolecular C—H bond functionalization/cyclization cascade of O-linkered cyclohexadienone-tethered 1,6-enynes is an economic and efficient way to construct this skeleton.The progress in the synthesis of hydrobenzofurans from cyclohexadienone-tethered 1,6-enynes via C—H bond functionalization/cyclization cascade catalyzed by different transition-metals is discussed.The relevant reaction modes,mechanisms and the selection of ligands for chiral control are mainly introduced.Finally,the challenges and development prospects in this field are also prospected and discussed.
作者
李志清
邱潇杨
孟楠
柳竹青
Li Zhiqing;Qiu Xiaoyang;Meng Nan;Liu Zhuqing(Advanced Research Institute for Multidisciplinary Science,Qilu University of Technology,Jinan 250353;Shandong Weifang Rainbow Chemical Co.Ltd.,Weifang,Shandong 250101)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第11期4306-4319,共14页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.22001140)
山东省自然科学基金(No.ZR2020QB002)资助项目.
