摘要
目的观察补充维生素D对初诊亚急性甲状腺炎患者临床指标及复发情况的影响。方法将初诊为亚急性甲状腺炎126例患者分为试验组(66例)和对照组(60例)。两组均予口服泼尼松6周;试验组加用维生素D_(2)注射液10 mg,每月1次肌肉注射。观察治疗前后临床指标的变化。随访12个月观察复发情况,进一步比较两组复发患者临床指标的特点。结果治疗前后,试验组患者ESR下降幅度较对照组更明显(P<0.05),FT_(3)和FT_(4)下降幅度及TSH上升幅度均较对照组稍大(P>0.05)。对照组复发率较试验组高(45.0%vs.24.2%)(P<0.05)。复发患者中,试验组发病时体温及上呼吸道感染比例低于对照组(P<0.05),而两组复发时间、颈痛、心悸、多汗发生率及FT_(3)、FT_(4)、TSH水平比较均无统计学差异(P>0.05)。结论补充维生素D对于亚急性甲状腺炎患者的急性病情缓解无明显作用,但可减少复发率,减轻复发症状。
Objective To observe the effects of vitamin D supplementation on clinical indicators and recurrence of the patients with newly diagnosed subacute thyroiditis.Methods A total of 126 patients with newly diagnosed subacute thyroiditis combined with decreased vitamin D were divided into two groups.The patients in group C(60 cases) were treated with oral prednisone for 6 weeks, and those in group A(66 cases) were given additional vitamin D_(2) injection 10 mg intramuscularly once a month.The changes of clinical indicators before and after treatment were observed.All the patients of the two groups were followed up for 12 months to observe the recurrence and its characteristics.Results Before and after treatment, the decrease of ESR in group A was more obvious than that in group C(P<0.05),and the decrease of FT;and FT;and the increase of TSH in group A were slightly greater than those in group C(P>0.05).The recurrence rate of group C was higher than that of group A(45.0% vs.24.2%)(P<0.05).Among the recurrent patients, body temperature and the proportion of upper respiratory tract infection at onset in group A were lower than those in group C(P<0.05).There were no statistical differences in the recurrence time, incidence of neck pain, palpitations, hypersweating and the levels of FT_(3),FT_(4) and TSH between two groups(P>0.05).Conclusion Vitamin D supplementation has no significant effect on the acute remission of the patients with subacute thyroiditis, but it can reduce the recurrence rate and alleviate the recurrence symptoms.
作者
周小莉
路晰媗
雷红
赵丹
ZHOU Xiaoli;LU Xixuan;LEI Hong(Department of Endocrinology,Cardiovascular and Cerebrovascular Hospital of General Hospital,Ningxia Medical University,Yinchuan 750000,CHINA)
出处
《江苏医药》
CAS
2021年第11期1107-1110,共4页
Jiangsu Medical Journal
基金
宁夏自然科学基金项目(2020AAC03424)。
