摘要
目的:观察参麦注射液联合头孢哌酮钠舒巴坦钠治疗老年重症感染的临床疗效及对肺功能的影响。方法:选择重症感染老年患者110例,按照随机数字表法分为对照组和观察组各55例。对照组在维持基础治疗的基础上加用头孢哌酮舒巴坦钠治疗,观察组在对照组的基础上加用参麦注射液治疗。比较2组治疗前后的体温、白细胞计数、血小板计数、降钙素原(PCT)、C-反应蛋白(CRP)、血清白蛋白(Alb)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC);统计2组临床治疗效果。结果:观察组临床疗效优于对照组,经秩和检验,差异有统计学意义(P<0.05)。治疗后,2组体温、白细胞计数均较治疗前降低(P<0.05),血小板计数较治疗前升高(P<0.05),且观察组各项指标改善较对照组更显著(P<0.05)。治疗后,2组血清PCT、CRP水平均较治疗前降低(P<0.05),Alb水平较治疗前升高(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。治疗后,2组FEV1、FVC水平均较治疗前增高(P<0.05),且观察组FEV1、FVC水平均高于对照组(P<0.05)。结论:参麦注射液联合头孢哌酮钠舒巴坦钠治疗重症感染老年患者,可更好地控制感染,改善肺功能,提高临床疗效。
Objective:To observe the clinical effect of Shenmai injection combined with cefoperazone and sulbactam sodium on the treatment of senile severe infection and its effect on the lung function.Methods:A total of 110 elderly patients with severe infection were selected and divided into the control group and the observation group according to random number table method,55 cases in each group.The control group was treated with cefoperazone and sulbactam sodium based on the basis of basic maintenance therapy,and the observation group was treated with Shenmai injection based on the treatment of the control group.The body temperature,white blood cell count,platelet count,procalcitonin(PCT),C-reactive protein(CRP),serum albumin(Alb),forced expiratory volume in the first second(FEV1)and forced vital capacity(FVC)in the two groups were compared before and after treatment.The clinical effect in the two groups were counted.Results:The clinical effect in the observation group was better than that in the control group,the difference being significant(P<0.05).After treatment,the body temperature and white blood cell count in the two groups were decreased when compared with those before treatment(P<0.05),and the platelet count was increased when compared with that before treatment(P<0.05);the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05).After treatment,the levels of serum PCT and CRP in both groups were decreased when compared with those before treatment(P<0.05),and the level of Alb was increased compared with that before treatment(P<0.05);the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05).After treatment,the levels of FEV1 and FVC in both groups were higher than those before treatment(P<0.05),and the above two levels in the observation group were higher than those in the control group(P<0.05).Conclusion:The therapy of Shenmai injection combined with cefoperazone and sulbactam sodium in th
作者
戚路磊
郑卫
QI Lulei;ZHENG Wei
出处
《新中医》
CAS
2021年第22期66-70,共5页
New Chinese Medicine
关键词
老年重症感染
参麦注射液
头孢哌酮钠舒巴坦钠
炎症因子
肺功能
Senile severe infection
Shenmai injection
Cefoperazone and sulbactam sodium
Inflammatory factor
Lung function
