摘要
肝纤维化相关疾病是一组发病率高、病因复杂、预后不良的疾病,但其发生机制尚不明,对于已经形成的肝纤维化病变也缺乏有效的逆转手段。最新研究发现环状RNA(circular RNA,circRNA)在肝纤维化及其相关疾病的发生、发展中起重要的调控作用。本文综述了circRNA在肝组织中的表达及其在肝纤维化过程中的调控作用、其在肝纤维化相关疾病中的调控作用、作用机制和差异性表达情况,以期为其在临床上相关疾病的靶向治疗研究提供新思路,为临床诊断寻找新的生物学标志物。
Liver fibrosis related diseases are a group of diseases with high incidence rate,complex etiology,and poor prognosis.However,the pathogenesis is still unknown,and there is also a lack of effective means for the reversal of liver fibrosis.Recent studies have found that circular RNA(circRNA)plays an important regulatory role in the occurrence and development of liver fibrosis and its related diseases.In order to provide new ideas for the targeted treatment of clinical related diseases,and find new biological markers for clinical diagnosis,this paper reviews the expression of circRNA in liver tissue,its regulatory role in the process of liver fibrosis,its regulatory role,mechanism and differential expression in liver fibrosis related diseases.
作者
罗鲲鹏(综述)
梁美惠(综述)
金世柱(审校)
LUO Kunpeng;LIANG Meihui;JIN Shizhu(Department of Gastroenterology,Second Affiliated Hospital of Harbin Medical University,Harbin 150081;Department of Function,Beitun Hospital,10th Division of Xinjiang Production and Construction Corps,Beitun Xinjiang 830000,China)
出处
《临床与病理杂志》
CAS
2021年第11期2684-2688,共5页
Journal of Clinical and Pathological Research
基金
新疆生产建设兵团重点领域科技攻关计划(2020AB020)。
关键词
环状RNA
肝纤维化
治疗靶点
诊断标志物
病理机制
circular RNA
liver fibrosis
therapeutic target
diagnostic markers
pathological mechanism
