摘要
血管钙化(vascular calcification,VC)是慢性肾脏病(chronic kidney disease,CKD)患者常见的血管病变,可加重心脏后负荷,可导致心脏缺血、左室肥厚和心力衰竭,从而导致透析患者心血管事件的发生率及死亡率的增高。血管钙化根据发生位置主要可分为内膜钙化和中膜钙化。VC在CKD中发病机制复杂,涉及多种因素和机制,且临床上尚缺乏有效的VC治疗方法。文章就目前血液透析患者VC的发生机制、诊断和治疗策略进行综述。
Vascular calcification(VC)is a common vascular lesion in patients with chronic kidney disease(CKD). It can aggravate cardiac afterloading,leading to ischemia,left ventricular hypertrophy and heart failure,and increasing the incidence of cardiovascular events and mortality in hemodialysis patients. Vascular calcification can be divided into intimal calcification and media calcification according to calcification site. The pathogenesis of VC in CKD is complex,involving a variety of factors and mechanisms,and there still remains a lack of effective treatment for VC in clinic. This paper reviews the pathogenesis,diagnosis and treatment strategies of VC in hemodialysis patients.
作者
万慧婷
邢昌赢
WAN Hui-ting;XING Chang-ying(Department of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Medical University,Nanjing 210029,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2021年第11期922-925,930,共5页
Chinese Journal of Practical Internal Medicine
基金
江苏省卫计委“科教强卫工程”创新团队(CXTDA2017011)。
关键词
血管钙化
慢性肾脏病
透析
vascular calcification
chronic kidney disease
dialysis
