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聚乙二醇干扰素α-2a注射液辅助治疗耐药慢性乙型病毒性肝炎的临床观察 被引量:2

Clinical observation of peginterferon alfa-2a solution for injection in adjuvant treatment of drug-resistant chronic hepatitis B
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摘要 目的探讨聚乙二醇干扰素α-2a注射液辅助治疗耐药慢性乙型病毒性肝炎的治疗效果。方法选取2017年2月至2018年10月确山县人民医院收治的慢性乙型病毒性肝炎患者102例,按治疗方法不同分为对照组51例和观察组51例。2组患者均行基础的保肝治疗,对照组患者给予聚乙二醇干扰素α-2a注射液治疗,观察组患者给予聚乙二醇干扰素α-2a注射液联合恩替卡韦联合治疗。观察并比较2组患者的天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBIL)等水平,以及在治疗中出现的不良反应。结果治疗前,2组患者的AST、ALT、TBIL等水平比较,差异无统计学意义(P>0.05),治疗后,2组均有所改善,且观察组改善的幅度大于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为12%(6/51),与对照组的10%(5/51)比较,差异无统计学意义(P>0.05)。结论采用聚乙二醇干扰素α-2a注射液辅助治疗耐药慢性乙型病毒性肝炎患者,能够有效改善患者的临床症状,安全性较好,值得推广。 Objective To explore the therapeutic effect of peginterferonα-2a solution for injection in adjuvant treatment of drug-resistant chronic hepatitis B.Methods A total of 102 patients with chronic hepatitis B who were admitted to Queshan county people′s hospital from February 2017 to October 2018 were selected and divided into control group and observation group according to trentment methods,with 51 cases in each group.Both groups of patients received basic liver-protection treatment,the control group was given peginterferonα-2a solution for injection,and the observation group was given peginterferonα-2a injection combined with entecavir.The levels of aspartate aminotransferase(AST),alanine transferase(ALT),serum total bilirubin(TBIL),as well as adverse reactions during treatment between the two groups were observed and compared.Results There were no statistically significant differences in the levels of AST,ALT,TBIL between the two groups of patients(P>0.05)before treatment.Both groups were improved,and the improvement in the observation group was greater than that in the control group after treatment,There were differences statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 12%(6/51),compared with 10%(5/51)in the control group,the difference was not statistically significant(P>0.05).Conclusion Adjuvant treatment of patients with drug-resistant chronic hepatitis B with peginterferonα-2a solution for injection can effectively improve the clinical symptoms of patients with good safety and is worthy of promotion.
作者 王绍乐 Wang Shaole(Department of Infectious Diseases,Queshan County People′s Hospital,Henan 463200,China)
出处 《实用医技杂志》 2021年第12期1435-1437,共3页 Journal of Practical Medical Techniques
关键词 干扰素Α 乙型肝炎病毒 抗药性 病毒 Interferon-alpha Hepatitis B virus Drug resistance,viral
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