摘要
目的探讨不良孕产史孕妇行胎儿染色体核型分析的意义。方法2017年12月-2019年11月空军军医大学西京医院接诊的不良孕产史孕妇共393例,经产前咨询后行胎儿染色体核型分析检查。按不良孕产史将病例分为4组。将孕育过染色体病患儿的孕妇95例设为A组,孕育过基因病患儿的孕妇80例设为B组,孕育过发病原因不明异常胎儿的孕妇185例设为C组,夫妻一方携带异常染色体33例设为D组;按有无合并其他检查指征将病例分为单纯不良孕产史组(291例)和合并检查指征组(102例)。分析各组胎儿染色体核型。结果共检出有临床意义的异常核型26例,异常核型检出率为6.62%。孕育过发病原因不明异常胎儿和夫妻一方携带异常染色体的病例的胎儿异常核型检出率较高,分别为5.95%和36.36%。单纯不良孕产史组与合并检查指征组的异常核型检出率均较高,分别为6.53%和6.68%。结论孕育过发病原因不明异常胎儿和夫妻一方携带异常染色体的病例胎儿异常核型检出率较高,对有不良孕产史的孕妇,无论是否合并其他检查指征,应根据既往不良孕产史选择适宜的筛查和诊断性检查。
Objective To investigate the significance of fetal chromosome karyotype analysis in pregnant women with adverse pregnancy history.Methods A total of 393 pregnant women with adverse pregnancy history were admitted to Xijing Hospital of Air Force Medical University from December 2017 to November 2019,and fetal karyotype analysis was performed after prenatal consultation.They were divided into four groups according to the history of adverse pregnancy,95 pregnant women with chromosomal diseases were set as group A,80 pregnant women with genetic diseases were set as group B,185 pregnant women with unexplained abnormal fetuses were set as group C,and 33 pregnant women with abnormal chromosomes were set as group D.And according to the presence or absence of other examination indications,they were divided into simple adverse pregnancy history group(291 cases)and combined examination indications group(102 cases).The abnormal karyotypes were statistically analyzed in each group.Results A total of 26 cases of abnormal karyotypes with clinical significance were detected,and the detection rate of abnormal karyotypes was 6.62%.The detection rate of fetal abnormal karyotype was higher in patients who have had abnormal fetuses with unknown causes and in cases that one spouse carries an abnormal chromosome,which was 5.95%and 36.36%,respectively.The detection rate of abnormal karyotype was both high in simple adverse pregnancy history group and combined examination indication group,which was 6.53%and 6.68%,respectively.Conclusion The detection rate of fetal abnormal karyotype was higher in cases who had given birth to abnormal fetuses with unknown causes and in cases with one partner carrying an abnormal chromosomal karyotype.For pregnant women with a history of abnormal pregnancy,appropriate screening and diagnostic tests should be chosen according to the causes of abnormal pregnancy history whether or not other inspection indications are incorporated.
作者
熊梦华
郑娇
徐慧
李佳
杨红
XIONG Meng-hua;ZHENG Jiao;XU Hui;LI Jia;YANG Hong(Department of Obstetrics and Gynecology,Xijing Hospital of Air Force Medical University,Xi'an 710032,Shaanxi,China)
出处
《医学信息》
2021年第23期135-137,共3页
Journal of Medical Information
基金
陕西省科技厅高校联合项目(编号:2020GXLH-Y-009)。
关键词
不良孕产史
羊水细胞培养
染色体核型分析
异常核型检出率
Abnormal pregnancy history
Amniotic fluid cell culture
Chromosome karyotype analysis
Abnormal karyotype detection rate
