摘要
目的探讨低剂量阿托伐他汀联合依折麦布对老年高脂血症患者的临床效果。方法本研究以我院于2018年12月至2020年12月收治的200例老年高脂血症患者作为研究对象,将其随机分为100例试验组和100例对照组。对照组以2个月为1个治疗周期,每日晚上服用1次阿托伐他汀。试验组以2个月为1个治疗周期,每日晚上让患者服用10 mg阿托伐他汀和10 mg依折麦布治疗。观察并比较两组患者的治疗效果、血脂水平、不良反应发生率、生活质量等方面的情况。结果试验组共95例患者治疗有效,5例患者治疗无效,治疗总有效率为95.00%;对照组共76例患者治疗有效,24例患者治疗无效,治疗总有效率为76.00%,试验组患者治疗总有效率明显比对照组高(χ^(2)=6.2201,P<0.05)。治疗开始前,试验组和对照组的HDL-C、LDL-C、TG、TC水平比较均无差异(P>0.05);在经过治疗后,试验组和对照组患者的HDL-C显著高于治疗前水平,LDL-C、TG、TC水平比治疗前要低,P<0.05,且试验组上述指标均优于对照组(P<0.05)。试验组共3例患者发生不良反应,发生率为3.00%;对照组共12例患者发生不良反应,发生率为12.00%。试验组患者不良反应发生率明显比对照组低(χ^(2)=1.0841,P<0.05)。试验组和对照组患者的生活质量均无显著差异(P>0.05);在经过治疗后,试验组患者的生活质量评分包括物质生活状态、社会功能、心理功能、躯体功能显著高于对照组患者(P<0.05)。结论低剂量阿托伐他汀联合依折麦布治疗老年高脂血症的临床效果,具有一定临床价值,值得在临床上加以广泛推广以及应用。
Objective To investigate the clinical effect of low-dose atorvastatin combined with ezetimibe on elderly patients with hyperlipidemia.Methods In this study,200 elderly patients with hyperlipidemia admitted to our hospital from December 2018 to December 2020 were taken as the research objects,and they were randomly divided into 100 experimental groups and 100 control groups.The control group took two months as a treatment cycle and took atorvastatin once every night.The experimental group took two months as a treatment cycle,and the patients were treated with 10 mg atorvastatin and 10 mg ezetimibe every night.Observe and compare the treatment effect,blood lipid level,incidence of adverse reactions,quality of life and other aspects of the two groups of patients.Results A total of 95 patients in the experimental group were treated effectively,5 patients were ineffective,and the total effective rate of treatment was 95.00%;a total of 76 patients in the control group were treated effectively and 24 patients were ineffective,and the total effective rate of treatment was 76.00%,the total effective rate of treatment for patients in the experimental group was significantly higher than that in the control group(χ^(2)=6.2201,P<0.05).Before treatment,there was no significant difference in the levels of HDL-C,LDL-C,TG and TC between the experimental group and the control group(P>0.05);after treatment,the HDL-C of the experimental group and the control group Significantly higher than the level before treatment,and the levels of LDL-C,TG and TC were lower than those before treatment(P<0.05),and the above indicators of the test group are better than those of the control group(P<0.05).A total of 3 patients in the experimental group had adverse reactions,with an incidence of 3%;a total of 12 patients in the control group had adverse reactions,with an incidence of 12%.The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(χ^(2)=1.0841,P<0.05).There was no significant di
作者
王怀方
WANG Huaifang(Department of Pharmacy,Hospital of Luzhong Mining Co.,Ltd.,Laiwu 271113,China)
出处
《中国医药指南》
2021年第33期25-27,共3页
Guide of China Medicine
