摘要
目的研究甘蓝强骨片对去卵巢骨质疏松模型大鼠的药效作用。方法SD大鼠分为空白对照组、模型对照组、雌二醇阳性对照组和甘蓝强骨片0.45、0.90、1.80 g·kg^(-1)3个剂量组,采用去卵巢方法制备骨质疏松模型。动物给药15 d后,测定血中无机钙、磷、碱性磷酸酶(alkaline phosphatase,ALP)含量,股骨密度,股骨干重和灰重,进行三点弯曲实验测定股骨最大载荷(N)。结果甘蓝强骨片0.45、0.90、1.80 g·kg^(-1)3个剂量组均能显著改善去卵巢骨质疏松模型大鼠血清中钙和磷的含量,提高股骨密度,增加股骨干重、灰重和最大负荷。其中甘蓝强骨片1.80 g·kg^(-1)剂量组对于改善大鼠血清中钙和磷含量最佳;甘蓝强骨片0.45 g·kg^(-1)剂量组对提高股骨密度效果最好;甘蓝强骨片0.90 g·kg^(-1)剂量组对增加大鼠干重和灰重的效果优于其他组;甘蓝强骨片0.45、1.80 g·kg^(-1)剂量组可以更好地增强股骨的最大载荷。结论甘蓝强骨片有较好的抗骨质疏松作用。
Objective To investigate the protective effect of Cabbage Qianggu Tablets on bone in ovariectomized induce osteoporosis in rats.Methods SD rats were divided into blank control group,model control group,estradiol positive control group and cabbage strong bone tablets 0.45,0.90,1.80 g·kg^(-1) dosage groups.Osteoporosis model of ovariectomized osteoporosis rats was established.After 15 days administration,the blood levels of inorganic calcium,phosphorus,alkaline phosphatase(ALP),femoral bone density,femoral dry weight and ash weight were measured,and the maximum femoral load(N)was determined by a three-point bending test.Results The serum calcium and phosphorus bone density,bone weight and maximum load of all the dosages of Cabbage Qianggu Tablets increased significantly in the treatment group.The 1.80 g·kg^(-1) group had the best improvement in serum calcium and phosphorus content;The 0.45 g·kg^(-1) group had the best effect on improving femoral bone density;The group of 0.90 g·kg^(-1) could increase the dry weight and gray weight better;The 0.45 and 1.80 g·kg^(-1) dose groups can better enhance the maximum load of the femur.Conclusion Cabbage Qianggu Tablets might be a potential medicine for ovariectomized-induced osteoporosis in rats.
作者
张婷
梁国栋
刘卫东
肖云峰
ZHANG Ting;LIANG Guodong;LIU Weidong;XIAO Yunfeng(Inner Mongolia Grand Pharmaceutical Co.,Ltd.,Huhhot 010010,China;Inner Mongolia Enterprise Key Laboratory of Innovative Mongolian Medicine Research,Huhhot 010010,China;The Center for New Drug Safety Evaluation and Research of Inner Mongolia Medical University,Huhhot 010110,China)
出处
《药学研究》
CAS
2021年第11期718-720,752,共4页
Journal of Pharmaceutical Research
基金
内蒙古重大专项:蒙医药现代化关键技术研究及蒙药产业化。
关键词
甘蓝强骨片
药效学
骨质疏松
去卵巢模型
Cabbage Qianggu Tablets
Pharmacodynamics
Osteoporosis
Ovariectomized
