摘要
目的分析糖尿病肾病尿毒症患者行血液透析治疗的预后。方法60例糖尿病肾病尿毒症患者,采用随机数字表法分为常规治疗组及高通量治疗组,每组30例。常规治疗组患者给予常规血液透析治疗,高通量治疗组给予高通量血液透析治疗。比较两组患者的生活质量评分,治疗前后的血肌酐、尿素氮、β_(2)-微球蛋白水平,疗效,不良事件发生率。结果高通量治疗组患者的生活质量评分为(86.78±3.01)分,高于常规治疗组的(74.21±2.12)分,差异具有统计学意义(P<0.05)。治疗后,两组患者的血肌酐、尿素氮、β_(2)-微球蛋白水平均低于本组治疗前,且高通量治疗组患者的血肌酐(89.01±11.75)μmol/L、尿素氮(4.25±0.34)mmol/L、β_(2)-微球蛋白(11.46±1.30)mg/L均低于常规治疗组的(109.57±23.29)μmol/L、(5.15±0.78)mmol/L、(13.21±3.41)mg/L,差异具有统计学意义(P<0.05)。高通量治疗组患者的总有效率96.67%高于常规治疗组的73.33%,差异具有统计学意义(P<0.05)。高通量治疗组患者的不良事件发生率6.67%低于常规治疗组的33.33%,差异具有统计学意义(P<0.05)。结论高通量血液透析对于糖尿病肾病尿毒症的治疗效果确切,可有效改善尿素氮、血肌酐、β_(2)-微球蛋白水平,减少皮肤瘙痒、心律失常发生率,提高患者的生活质量。
Objective To analyze the prognosis of hemodialysis in patients with diabetic nephropathy and uremia.Methods A total of 60 patients with diabetic nephropathy and uremia were randomly divided into the conventional treatment group and the high-flux treatment group according to random numerical table,with 30 cases in each group.The conventional treatment group was treated with conventional hemodialysis,and the high-flux treatment group was treated with high-flux hemodialysis.Both groups were compared in terms of quality of life scores,blood creatinine,urea nitrogen,β_(2)-microglobulin before and after treatment,efficacy,and incidence of adverse events.Results The quality of life score in the high-flux treatment group was(86.78±3.01)points,which was higher than(74.21±2.12)points of the conventional treatment group,and the difference was statistically significant(P<0.05).After treatment,the blood creatinine,blood urea nitrogen,andβ_(2)-microglobulin of the two groups were lower than those of this group before treatment;the serum creatinine(89.01±11.75)μmol/L,blood urea nitrogen(4.25±0.34)mmol/L,andβ_(2)-microglobulin(11.46±1.30)mg/L of the high-flux treatment group were all lower than(109.57±23.29)μmol/L,(5.15±0.78)mmol/L,and(13.21±3.41)mg/L of the conventional treatment group;all the differences were statistically significant(P<0.05).The total effective rate 96.67%in the high-flux treatment group was higher than 73.33%in the conventional treatment group,and the difference was statistically significant(P<0.05).The incidence of adverse events 6.67%in the high-flux treatment group was lower than 33.33%in the conventional treatment group,and the difference was statistically significant(P<0.05).Conclusion High-flux hemodialysis has definite effect on patients with diabetic nephropathy and uremia,which can effectively improve the blood urea nitrogen,serum creatinine andβ_(2)-microglobulin,reduce the incidence of skin itching and arrhythmia,and improve the quality of life of patients.
作者
白明鑫
BAI Ming-xin(Traditional Chinese Medicine Hospital of Shuncheng District(Fushuncheng Street Community Health Service Center of Shuncheng District),Fushun 113006,China)
出处
《中国实用医药》
2021年第32期63-65,共3页
China Practical Medicine
关键词
糖尿病肾病
尿毒症
血液透析
高通量
预后价值
Diabetic nephropathy
Uremia
Hemodialysis
High-flux
Prognostic value
