摘要
本文聚焦海关口岸芬太尼类新精神活性物质及其衍生物监管的业务需求及难点,重点概述了新型毒品-芬太尼类新精神活性物质的典型结构,浅析其药理药效及其滥用引发的危害,梳理芬太尼类新精神活性物质及其衍生物检测方法,整理芬太尼类物质的高效液相色谱法、液相色谱-质谱法、气相色谱-质谱法等分析方法,并对其红外光谱特征峰官能团进行解谱分析,为芬太尼类新精神活性物质的检测及监管提供技术支撑。
This paper focused on the business needs and difficulties of the supervision of fentanyl new psychoactive substances and their derivatives at the customs port,and summarized the typical structures of fentanyl analogues,a class of new-type drugs,and analyzed their pharmacological effects and harms caused by their abuse.Meanwhile,the regulations and the detection methods of fentanyl and its derivatives in China are briefly reviewed.The analytical methods,such as high-performance liquid chromatography,liquid chromatography-mass spectrometry(LC-MS)and gas chromatography-mass spectrometry(GC-MS),were collected and sorted,and the IR spectra of fentanyl compounds be compared with the functional groups of characteristic peaks,which would provide technical supports for the regulation of fentanyl analogues in China.
作者
李学洋
张婧
杨永超
李晶
杨雪
李宁涛
LI Xueyang;ZHANG Jing;YANG Yongchao;LI Jing;YANG Xue;LI Ningtao(Technical Center for Safety of Industrial Products of Tianjin Customs,Tianjin,300308)
出处
《中国药物依赖性杂志》
CAS
CSCD
2021年第5期392-398,共7页
Chinese Journal of Drug Dependence
基金
2019海关总署科研资助项目(2019HK002)。
关键词
芬太尼
药理药效
滥用危害
检测方法
fentanyl analogues
pharmacological effect
abuse harm
detection methods
