摘要
目的探讨血清半乳糖凝集素-3(Gal-3)与急性心肌梗死(AMI)患者新发心房颤动(AF)的关联性。方法选择2018年10月至2019年12月广西壮族自治区人民医院收治的AMI合并新发AF患者30例(新发AF组),另选同期AMI未合并新发AF患者30例(非AF组)。通过医院病历系统收集两组的临床资料,采用多因素logistic回归分析影响AMI患者新发AF的因素,采用Pearson相关分析探讨Gal-3与B型利钠肽前体(NT-proBNP)、左房前后径的相关性。结果新发AF组左心房前后径、NT-proBNP和血清Gal-3水平高于非AF组,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,较高水平的血清Gal-3是促进AMI患者新发AF的危险因素(OR=2.719,P=0.006)。AMI患者的血清Gal-3水平与NT-proBNP水平、左心房前后径呈显著正相关(P<0.05)。结论血清Gal-3水平与AMI患者新发AF密切相关,具有作为预测AMI患者新发AF标志物的潜力。
Objective To investigate the association between serum galectin-3(Gal-3)and new-onset atrial fibrillation(AF)in patients with acute myocardial infarction(AMI).Methods From October 2018 to December 2019,30 patients with AMI complicated with new-onset AF who were admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region were selected as the new-onset AF group,and 30 patients with AMI but without new-onset AF during the same period were selected as the non-AF group.The clinical data of the two groups were collected through the hospital medical record system.Multivariate logistic regression analysis was used to analyze the factors influencing new-onset AF in the AMI patients,and Pearson correlation analysis was used to investigate the correlation between Gal-3 and N-terminal prohormone of brain natriuretic peptide(NT-proBNP)and the anteroposterior diameter of the left atrium.Results The anteroposterior diameter of the left atrium,the levels of NT-proBNP and serum Gal-3 in the new-onset AF group were higher than those in the non-AF group,and the differences were statistically significant between the two groups(P<0.05).The results of multivariate logistic regression analysis showed that a higher level of serum Gal-3 was a risk factor for the development of new-onset AF in the AMI patients(OR=2.719,P=0.006).The levels of serum Gal-3 in the AMI patients were significantly positively correlated with the levels of NT-proBNP and the anteroposterior diameter of the left atrium(P<0.05).Conclusion Serum Gal-3 level is closely related to new-onset AF in patients with AMI,and has the potential to be used as a marker for predicting new-onset AF in AMI patients.
作者
李庆宽
覃绍明
卢志红
刘开有
LI Qing-kuan;QIN Shao-ming;LU Zhi-hong(Department of Cardiology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China)
出处
《中国临床新医学》
2021年第11期1116-1119,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西卫生健康委科研课题项目(编号:Z20180756)。
关键词
半乳糖凝集素-3
急性心肌梗死
心房颤动
Galectin-3(Gal-3)
Acute myocardial infarction(AMI)
Atrial fibrillation(AF)
