摘要
肿瘤坏死因子受体相关因子6(TRAF6)是一种重要的细胞质连接分子,属于肿瘤坏死因子超家族和Toll样/白细胞介素-1受体超家族。TRAF6在许多组织中均表达,特别是在脑、肺、肝、骨骼肌和肾脏中表达较丰富。TRAF6在常见女性生殖系统疾病(如宫颈癌、卵巢癌、子宫内膜炎、子宫平滑肌瘤和卵巢早衰)中的功能多样、作用机制复杂,且存在表达失调,TRAF6的异常表达与妇科恶性肿瘤及炎症性疾病等密切相关,对疾病诊断和治疗具有潜在价值,可能是未来的研究方向之一。
Tumor necrosis factor receptor-associated factor 6(TRAF6)is an important cytoplasmic junction molecule,which belongs to the tumor necrosis factor superfamily and Toll-like/interleukin-1 receptor superfamily.It is normally expressed in many tissues,especially abundant in the brain,lungs,liver,skeletal muscles,and kidneys.TRAF6 has diverse functions,complex mechanism of action and dysregulation of expression in common female reproductive system diseases(such as cervical cancer,ovarian cancer,endometritis,uterine leiomyoma and premature ovarian failure).The abnormal expression of TRAF6 is closely related to malignant gynecologic tumors and inflammatory diseases,which has potential value for the disease diagnosis and treatment,and may be one of the research directions in the future.
作者
黄锦源
代荫梅
HUANG Jinyuan;DAI Yinmei(Department of Gynecology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《医学综述》
CAS
2021年第21期4222-4227,共6页
Medical Recapitulate
关键词
妇科疾病
肿瘤坏死因子受体相关因子6
宫颈癌
卵巢癌
子宫内膜炎
Gynecologic diseases
Tumor necrosis factor receptor-associated factor 6
Cervical cancer
Ovarian cancer
Endometritis
