摘要
除了手术、放疗和化疗等传统手段外,免疫治疗作为一种新型的肿瘤治疗方法已引起人们的广泛关注.大量研究表明,多功能纳米探针可以实现肿瘤的成像与治疗,同时利用纳米探针诱导肿瘤细胞死亡还可导致肿瘤抗原的释放,引起肿瘤免疫治疗的特异性免疫反应,因此将免疫治疗与多功能纳米探针相结合,可实现肿瘤的早期诊断与治疗.本文主要综述了多功能纳米探针用于荧光成像、CT成像以及磁共振成像等引导下的免疫治疗的研究进展,并对其前景进行了展望.
Immunotherapy has attracted extensive attention as an effective means for tumor treatment instead of traditional methods such as surgery,radiotherapy,and chemotherapy.The combination of immunotherapy and multifunctional nanoprobes can realize the early diagnosis and treatment of tumors.Various studies have shown that multifunctional nanoprobes can achieve multi-mode imaging and the multi-mode treatment of tumors.Meanwhile,tumor cell death induced by some nanoprobes can lead to the release of tumor antigen to promote specific immune response to tumor immunotherapy.In this paper,we review the application and development prospect of multifunctional nanoprobes for immunotherapy combined with fluorescence imaging,computed tomography imaging,and magnetic resonance imaging.
作者
宣扬
侯效林
刘波
赵元弟
XUAN Yang;HOU XiaoLin;LIU Bo;ZHAO YuanDi(Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics&Molecular Imaging Key Laboratory,Department of Biomedical Engineering,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China;Key Laboratory of Biotechnology and Bioresources Utilization,Ministry of Education,Dalian Minzu University,Dalian 116600,China;Key Laboratory of Biomedical Photonics(HUST),Ministry of Education,Huazhong University of Science and Technology,Wuhan 430074,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2021年第11期1532-1541,共10页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2017YFA0700402)
国家自然科学基金(批准号:81771878,81971658,91959109)
辽宁省-沈阳材料科学国家研究中心联合研发基金(批准号:2019JH3/30100011)
华中科技大学自主创新研究基金(批准号:2016YXMS253,2017KFXKJC002,2018KFYXKJC048)资助。
