摘要
慢性肾脏病在我国成年人中的患病率高达10.8%,其并发症大多预后不良,已经成为我国公共卫生健康的重大问题。因此,寻找早期识别肾脏损伤的特异性生物标志物是急需解决的问题。致癌性抑制基因2蛋白(ST2)是IL-1受体家族成员之一,在多种疾病的炎症、纤维化及应激等状态下,能够触发与IL-33的结合,从而引发多种病理生理学效应,而可溶性ST2则能够作为“诱饵”受体抑制这些过程。近来年发现可溶性ST2能够作为肾脏损伤及其进展的标志物。本文对可溶性ST2的生物结构特点及其在肾脏疾病早期损伤及预后中的作用进行综述,为早期发现并预防肾脏疾病提供新思路。
The prevalence of chronic kidney disease in Chinese adults is as high as 10.8 percent,and most of its complications have poor prognosis,which has become a major problem of public health in China.Therefore,finding specific biomarkers for early recognition of kidney injury is an urgent problem to be solved.As a member of IL-1 receptor family,the suppression of tumorigenicity 2 protein(ST2)can start combination with IL-33 under the conditions of inflammation,fibrosis,and stress in many diseases,thereby triggering a variety of pathophysiological effects,while the soluble form of ST2 can act as a“decoy”receptor to inhibit these processes.In recent years,it has been discovered that soluble ST2 can be used as a marker of renal injury and progression.This article reviewed both the biological structural characteristics of soluble ST2 and its role in the early injury and prognosis of renal diseases,in order to provide new ideas for early detection and prevention of renal diseases.
作者
张亚伟
王兴智
Zhang Yawei;Wang Xingzhi(Department of Nephrology, First Hospital Affiliated to Harbin Medical University, Harbin 150001, Heilongjiang Province, China)
出处
《中华肾病研究电子杂志》
2021年第5期292-295,共4页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
