摘要
目的:探讨紫花地丁清热颗粒剂的制备工艺,探讨制颗粒的方法筛选,制颗粒的各种影响因素。为拓展中医药经典制剂的开发和临床应用提供实验依据。方法:对中药提取工艺进行筛选,通过正交实验得出最佳提取方案。对主药、辅料及干燥温度进行一般性考察,通过湿法制粒进行制粒。最终最优的制粒配比为浸膏与混合辅料质量比1∶3、可溶性淀粉与糊精质量比1∶2、干燥温度为70℃。最后,根据《中国药典》2015版对所制颗粒进行一般性质量检查。结论:所制颗粒色泽均匀,颗粒蓬松,易于溶解且颗粒干燥,紫花地丁清热颗粒剂制备方法工艺可行。
Objective:To study the preparation technology of Zihua Diding Granule,to explore the method of making granules and the various influencing factors.To provide experimental basis for the development and clinical application of traditional Chinese medicine classic preparations.Methods:The extraction technology of traditional Chinese medicine was screened and the optimum extraction scheme was obtained by orthogonal experiment.The main medicine,excipients and drying temperature were investigated in general,and granulation was carried out by wet granulation.The final optimum granulation ratio is the ratio of extract to mixed excipients 1∶3,soluble starch and dextrin 1∶2,and the drying temperature is 70℃.Finally,according to the 2015 edition of the Chinese Pharmacopoeia,the general quality inspection of the prepared particles was carried out.Conclusion:The prepared granules are uniform in color,loose in canopy,easy to dissolve and dry in granules.
作者
胡健力
吕岩
张爱娇
Hu Jianli;Lyu Yan;Zhang Aijiao(School of Pharmacy,Anhui Xinhua University,Hefei 230088,China)
出处
《山东化工》
CAS
2021年第21期24-26,29,共4页
Shandong Chemical Industry
基金
2020安徽省级大创项目(AH202012216109)。