摘要
牛结节性皮肤病可对病畜皮肤造成永久性损害,并会导致产奶量下降、生长发育迟缓、公畜不育和孕畜流产等严重后果,对经济生产具有重要影响。目前尚无治疗该病的特效药,使用安全有效的疫苗是防控该病传播的重要手段。牛结节性皮肤病弱毒活疫苗在许多国家已被成功用于该病的防控,除此之外,由于牛结节性皮肤病病毒与山羊痘病毒及绵羊痘病毒在基因组序列上的高度相似性,山羊痘病毒弱毒活疫苗和绵羊痘病毒弱毒活疫苗在许多地区也被用于该病的防控。牛结节性皮肤病病毒编码基因较多,目前尚未发现基因缺失疫苗和亚单位疫苗具有好的保护效果。近年来灭活疫苗在实验室研究中取得了较大进展,但仍需进一步大规模临床试验以证明其有效性。此外,牛结节性皮肤病病毒作为一种痘病毒,已被证明是表达多种病原微生物抗原的有效载体之一。笔者主要总结了当前牛结节性皮肤病疫苗的研究进展,对弱毒疫苗、灭活疫苗、基因缺失疫苗和亚单位疫苗的使用情况、保护效果及研究方向等方面进行了综述,以期为牛结节性皮肤病疫苗的研发和疫病的防控提供新的思路和见解。
Lumpy skin disease causes permanent damage to the skin of infected animals and leads to serious symptoms such as reduction of milk production,growth retardation,infertility of male animals and pre-mature miscarriage of females.As a result,the disease poses an essential threat to economy.Currently,there are no specific antiviral treatments for the disease,and the use of safe and effective vaccine constitutes a major way to prevent and control the spread of the disease.Lumpy skin disease virus attenuated vaccines have been successfully used in the control in many countries.In addition,due to the high similarity of genome sequence in Sheeppox virus,attenuated vaccines of Goatpox virus,Goatpox virus and Sheeppox virus have also been used in the control of Lumpy skin disease virus.Lumpy skin disease virus codes a large number of genes,the current research results have not found that the gene deletion vaccine and subunit vaccine have good protective effect.Inactivated vaccines have shown encouraging results in laboratory studies in recent years,but further large-scale clinical trials are still needed to prove their effectiveness.Finally,as a kind of Poxvirus,Lumpy skin disease virus has been proved to be one of the effective vectors for expressing various pathogenic antigens.This article mainly discussed the current vaccines available for Lumpy skin disease virus,including the application,protection effect,research direction of attenuated vaccines,inactivated vaccines,gene-deleted vaccines,and subunit vaccines,so as to provide novel insights into the development of vaccines and therapeutics for Lumpy skin disease virus in the future.
作者
谢士杰
朱俊达
王天坤
胡鑫
魏雯娟
吴文学
彭辰
XIE Shijie;ZHU Junda;WANG Tiankun;HU Xin;WEI Wenjuan;WU Wenxue;PENG Chen(College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Animal Disease Control and Prevention of Changping District,Beijing 102200,China;Beijing Sunlon Livestock Development Limited Company,Beijing 102202,China)
出处
《中国畜牧兽医》
CAS
北大核心
2021年第11期4220-4230,共11页
China Animal Husbandry & Veterinary Medicine
基金
现代农业(奶牛)产业技术体系建设专项资金资助(CARS-36)。
