摘要
缺氧性肺动脉高压(HPH)是指由于长期缺氧导致血管内皮细胞损伤,血管活性因子水平失调,以血管收缩及血管重塑为主要病理表现的一类肺动脉高压症(PAH),HPH发病率高,死亡率高,除了肺移植,目前尚无根治办法,对于HPH的治疗一直是研究热点,本文将结合近年国内外最新研究从基因靶向、离子通道、线粒体、NO相关药物、西药、中药领域对HPH的治疗做一概述。
Hypoxic pulmonary hypertension(HPH)refers to a type of pulmonary arterial hypertension(PAH)with vasoconstriction and vascular remodeling as the main pathological manifestations of vascular endothelial cell damage caused by long-term hypoxia,the incidence of HPH High mortality rate.Except for lung transplantation,there is currently no cure.The treatment of HPH has always been a research hotspot.This article will combine the latest research at home and abroad in recent years from gene targeting,ion channels,mitochondria,NO-related drugs,western medicine,and traditional Chinese medicine.The field gives an overview of the treatment of HPH.
作者
钟士杰
邓堂
林开文
廖勇
魏胜超
李奇
徐双琴
云宏芳
金桂云
ZHONG Shi-jie;DENG Tang;LIN Kai-wen;LIAO Yong;WEI Sheng-chao;LI Qi;XU Shuang-qin;YUN Hong-fang;JIN Gui-yun(Department of Emergency and critical Medicine,the first affiliated Hospital of Hainan Medical University,Haikou,Hainan,570000,China;Key Laboratory of Emergency and Trauma of Hainan Medical University,Ministry of Education,Haikou,Hainan,570000,China)
出处
《现代生物医学进展》
CAS
2021年第18期3596-3600,共5页
Progress in Modern Biomedicine
基金
安徽省高校自然科学研究项目(KJ2017A262)。
关键词
缺氧性肺动脉高压
HPH
治疗
机制
Hypoxic pulmonary hypertension
HPH
Treatment
Mechanism
