摘要
目的探究藤黄健骨胶囊联合艾瑞昔布片治疗膝骨关节炎的临床疗效。方法选取2018年1月-2020年12月开封市人民医院收治的112例膝骨关节炎为研究对象,按照随机数字表法分为对照组和治疗组,每组各56例。对照组餐后口服艾瑞昔布片,2次/d,0.1 g/次;治疗组患者在对照组基础上餐后口服藤黄健骨胶囊,2次/d,1 g/次。两组患者治疗8周。观察两组患者临床疗效,比较治疗前后两组患者血清白细胞介素-1β(IL-1β)、IL-17、IL-23和胰岛素样生长因子1(IGF-1)水平,及视觉模拟法评分(VAS)和膝关节功能(Lysholm)评分。结果治疗后,治疗组总有效率为92.86%,显著高于对照组的83.93%(P<0.05)。治疗后,两组患者血清IL-1β、IL-17、IL-23、IGF-1水平均明显下降(P<0.05),且治疗组更明显(P<0.05)。治疗后,两组患者VAS评分明显降低,而Lysholm评分明显升高(P<0.05),且治疗组患者评分明显好于对照组(P<0.05)。结论藤黄健骨胶囊联合艾瑞昔布片治疗膝骨关节炎,能够明显改善患者炎症反应,缓解疼痛程度,提高膝关节功能恢复效率和临床疗效。
Objective To explore the clinical efficacy of Tenghuang Jiangu Capsules combined with irecoxib in treatment of knee osteoarthritis. Methods Patients(112 cases) with knee osteoarthritis in Kaifeng People’s Hospital from January 2018 to December 2020 were divided into control and treatment groups according the random number table method, and each group had 56 cases. Patients in the control group were po administered with Imrecoxib Tablets after meal, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Tenghuang Jiangu Capsules after meal, 1 g/time, twice daily. Patients in two groups were treated for 8 weeks.After treatment, the clinical efficacy was evaluated, the levels of serum IL-1β, IL-17, IL-23 and IGF-1, the VAS and Lysholm knee scores in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 92.86%, which was significantly higher than 83.93% of the control group(P < 0.05). After treatment, the levels of serum IL-1β, IL-17, IL-23 and IGF-1 in two groups were significantly decreased(P < 0.05), especially in the treatment group(P < 0.05).After treatment, the VAS scores in two groups were significantly decreased, while the Lysholm scores were significantly incre ased(P < 0.05), and the scores of the treatment group were significantly better than those of the control group(P < 0.05). Conclusion Tenghuang Jiangu Capsules combined with irecoxib in treatment of knee osteoarthritis can significantly improve the inflammatory response, relieve the degree of pain, and improve the recovery efficiency of knee joint function and clinical effect.
作者
何浩
于凯
刘海燕
郑军卯
王辉
HE Hao;YU Kai;LIU Hai-yan;ZHENG Jun-mao;WANG Hui(Department of Orthopedics,Kaifeng People’s Hospital,Kaifeng 475000,China;Department of Orthopedics,Minquan Hospital of TCM,Shangqiu 476800,China;Department of Surgery,Minquan People’s Hospital,Shangqiu 476800,China)
出处
《现代药物与临床》
CAS
2021年第10期2107-2110,共4页
Drugs & Clinic
基金
开封市科技局计划发展项目(1703007)。
