摘要
卒中后抑郁会严重影响卒中患者转归和生活质量。然而,由于诊断率较低,导致大量卒中后抑郁患者并未得到及时救治而转归不佳。因此,只有早期发现、早期诊断和早期治疗卒中后抑郁,才能提高卒中患者的预后和生活质量。近年来,大量血清生物标志物研究尝试寻找与卒中后抑郁相关的客观指标。其中,白细胞介素-18因其多态性以及在脑内组成型表达的特点,尤其是血清水平变化在急性缺血性卒中风险分层及转归中的作用,使其与卒中及卒中后抑郁的发病机制建立了关联性。文章对白细胞介素-18在卒中后抑郁发病机制中的作用进行了综述。
Post-stroke depression(PSD)can seriously affect the outcome and quality of life of patients with stroke.However,due to the lower diagnostic rate,a large number of patients with PSD have not been treated in time and have a poor outcome.Therefore,only early detection,early diagnosis and early treatment of PSD can improve the prognosis and quality of life of patients with stroke.In recent years,a large number of studies on serum biomarkers have tried to find objective indicators related to PSD.Among them,interleukin-18 is associated with the pathogenesis of stroke and PSD,which may be attributed to its polymorphism and constitutive expression in the brain,especially the role of serum level changes in the risk stratification and outcome of acute ischemic stroke.This article reviews the role of interleukin-18 in the pathogenesis of PSD.
作者
仇慧慧
尹榕
Qiu Huihui;Yin Rong(Graduate School of the First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Hospital of the Joint Logistics Support Force of the Chinese people's Liberation Army,Lanzhou 730050,China)
出处
《国际脑血管病杂志》
2021年第9期693-697,共5页
International Journal of Cerebrovascular Diseases
