期刊文献+

四氢异喹啉酰胺类化合物的设计与合成

Design and Synthesis of Tetrahydroisoquinoline Amide Compounds
下载PDF
导出
摘要 目的:设计、合成四氢异喹啉酰胺类化合物,为开发更为安全、有效的抗血小板聚集候选药物提供参考。方法:依据药物化学中的拼合原理,设计含有四氢异喹啉母核和阿魏酸结构的四氢异喹啉酰胺类化合物。以取代苯甲酸、胡椒乙胺、乙酰阿魏酸为起始原料,通过酰胺化反应、Bischler-Napieralski反应、水解反应、亲核取代反应等步骤对其进行合成。结果:设计了2个四氢异喹啉酰胺类化合物。按照合成步骤对其进行了合成,2个化合物的结构均经^(1)H-NMR、^(13)C-NMR、MS谱图佐证。结论:设计、合成了2个四氢异喹啉酰胺类化合物,为抗血小板聚集药物开发研究提供参考。 Objective:To design and synthesize tetrahydroisoquinoline amide compounds to provide reference for the development of more safe and effective anti platelet aggregation candidate drugs.Methods:According to the principle of drug combination,tetrahydroisoquinoline amide compounds containing tetrahydroisoquinoline mother nucleus and ferulic acid structure were designed.Designed compounds were synthesized by amidation reaction,Bischler napieralski reaction,hydrolysis reaction and nucleophilic substitution reaction.Their starting materials were substituted by benzoic acid,piperonethylamine and acetylferulic acid.Results:Two tetrahydroisoquinoline amide compounds were designed and synthesized.Their structures were confirmed by ^(1)H-NMR,^(13)C-NMR and MS spectra.Conclusion:Two tetrahydroisoquinoline amide compounds were designed and synthesized,which can provide reference for the development of anti platelet aggregation drugs.
作者 汤泉 张晖 张俊杰 TANG Quan;ZHANG Hui;ZHANG Junjie(Public Basic School,Bengbu Medical College,Bengbu 233030,China)
出处 《安徽科技学院学报》 2021年第4期77-81,共5页 Journal of Anhui Science and Technology University
基金 安徽省高校自然科学研究项目(KJ2019A0390)。
关键词 四氢异喹啉 酰胺类化合物 设计 合成 Tetrahydroisoquinoline Amide compounds Design Synthesis
  • 引文网络
  • 相关文献

参考文献13

二级参考文献73

共引文献122

;
使用帮助 返回顶部