摘要
目的探讨糖尿病肾病患者的临床特点及预后的影响因素。方法回顾性分析2017年8月至2019年8月西安市第九医院肾脏内科收治的82例糖尿病肾病患者的临床诊治资料,根据患者治疗后的临床预后情况分为有效组(n=43)和无效组(n=39),比较两组患者的性别、年龄、病程、心率(HR)、体质量指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血压、血脂、肝肾功能等一般资料,采用Logistic多因素回归分析影响糖尿病肾病患者预后的相关因素。结果82例糖尿病肾病患者中,男性43例,女性39例;年龄大于50岁者33例;病程5年以上者48例;合并肥胖者35例,合并高血压者28例,合并心脏病者6例,合并脂肪肝者26例。单因素分析结果显示,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、24 h平均收缩压(24 h SBP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、血肌酐(Scr)是糖尿病肾病患者临床预后的影响因素(P<0.05)。经Logistic多因素回归分析结果显示,24 h SBP、ALT、AST、BUN、Scr是糖尿病肾病患者临床预后的独立影响因素(OR=2.280、1.042、2.307、1.570、1.413,P<0.05)。结论糖尿病肾病患者男女比例为1.10:1,多为5年及以上病程患者;24 h平均收缩压、肝功能、肾功能是影响糖尿病肾病患者临床预后的独立因子,血压越高,肝功能、肾功能越差,患者预后越倾向不良。
Objective To investigate the clinical characteristics of patients with diabetic nephropathy(DN)and the influencing factors of prognosis.Methods A retrospective analysis was performed on the clinical diagnosis data of82 patients with DN admitted to Department of Nephrology of Xi’an Ninth Hospital between August 2017 and August2019.According to clinical prognosis after treatment,they were divided into the effective group(n=43)and ineffective group(n=39).The general data such as gender,age,course of disease,heart rate(HR),body mass index(BMI),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1 c),blood pressure,blood lipid and liver-kidney function were compared between the two groups.The influencing factors of prognosis in DN patients were analyzed by logistic regression model.Results Among the 82 DN patients,there were 43 males and 39 females.There were 33 cases over 50 years,48 cases with disease course over 5 years,35 cases with obesity,28 cases with hypertension,6 cases with heart disease and 26 cases with fatty liver.The results of univariate analysis showed that triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),24 h mean systolic blood pressure(24 h SBP),alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen(BUN)and serum creatinine(Scr)were influencing factors of clinical prognosis in DN patients(all P<0.05).The results of logistic multivariate regression analysis showed that 24 hSBP,ALT,AST,BUN and Scr were independent influencing factors of clinical prognosis in DN patients(OR=2.280,1.042,2.307,1.570,1.413,all P<0.05).Conclusion The ratio of male to female in DN patients is1.10:1.The disease course in most of them is over 5 years.The 24 h mean SBP,liver function and kidney function are independent factors that affect the clinical prognosis of DN patients.The higher the blood pressure and the worse the liver and kidney function,the worse the prognosis of patients.
作者
冯玲
梁维
赵静
何志婷
魏玲云
黄丽丽
许晓丽
FENG Ling;LIANG Wei;ZHAO Jing;HE Zhi-ting;WEI Ling-yun;HUANG Li-li;XU Xiao-li(Department of Nephrology,Xi'an Ninth Hospital,Xi'an 710054,Shaanxi,CHINA;Department of Endocrine,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,Shaanxi,CHINA)
出处
《海南医学》
CAS
2021年第22期2915-2917,共3页
Hainan Medical Journal
关键词
糖尿病肾病
临床特点
预后
影响因素
肝功能
肾功能
Diabetic nephropathy(DN)
Clinical characteristic
Prognosis
Influencing factor
Liver function
Kidney function
