摘要
远处转移是乳腺癌患者死亡的主要原因,大多数晚期乳腺癌是不可治愈的。寡转移是介于局限期和广泛转移的一种中间状态。放疗在寡转移性乳腺癌的局部治疗中发挥着非常重要的作用。随着立体定向放疗(SBRT)技术的发展,可以予以根治剂量,同时保护周围的正常组织。既往研究证明SBRT是安全有效的,对乳腺癌的骨、肺、肝、脑、淋巴结等寡转移的局控率>80%。但是,如何筛选真正的寡转移还存在一定争议,进一步的随机临床研究证实放疗能否改善患者生存是至关重要的。
Distant metastasis is the leading cause of death for breast cancer patients,and advanced metastatic breast cancer is mainly considered incurable.Oligometastasis is an"intermediate stage"between local primary tumor and extensive metastasis.As a local treatment approach,radiotherapy plays an important role in the management of oligometastatic breast cancer.The development of stereotactic body radiotherapy(SBRT)allows the delivery of ablative doses to the targets without exceeding the dose constraints of organs-at-risk.Studies have shown that SBRT is safe and effective,with local control rates of more than 80%for breast cancer oligometastasis to the bone,lung,liver,brain,and lymph nodes.However,how to screen the true oligometastasis remains controversial.Randomized clinical trials will be essential to confirm whether SBRT can improve the survival outcomes.
作者
宋玉春
王淑莲
Song Yuchun;Wang Shulian(Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2021年第11期1221-1225,共5页
Chinese Journal of Radiation Oncology
关键词
肿瘤寡转移
乳腺/立体定向放射疗法
研究进展
Neoplasm oligometastasis
breast/stereotactic body radiotherapy
Research progress
