摘要
硫化氢(hydrogen sulfide,H_(2)S)在抑制中性粒细胞胞外捕网(neutrophil extracellular traps,NETs)的形成中发挥重要的生理作用。H_(2)S通过多种途径抑制NETs的形成,包括抑制血小板活化介导的NETs产生,上调miR-16-5P抑制其目标基因磷酸肌醇-3-激酶调节亚基1(phosphoinositide-3-kinase regulatory subunit 1,PIK3R1)和RAF1的表达,抑制丝裂原活化蛋白激酶家族(mitogen-activated protein kinases,MAPKs)细胞外信号调节蛋白激酶(extracellular signal-regulated kinase,ERK)途径,减少活性氧(reactive oxygen species,ROS)及呼吸爆发,降低自噬和细胞内钙离子水平等。文章就硫化氢类药物及其衍生制品的研发和应用、NETs相关疾病的临床防治进行了综述。
The hydrogen sulfide(H_(2)S)plays a crucial physiological role on inhibiting neutrophil extracellular traps(NETs)formation.Hydrogen sulfide regulates the formation of NETs through a variety of pathways,including inhibition of platelet activation mediated NETs production,up-regulation of MiR-16-5p that inhibits the expression of target genes PI3KR1 and RAF1,inhibition ofthe MAPK family ERK protein kinase pathway,reduction of ROS and respiratory burst levels,and reduction of autophagy and intracellular calcium levels.The development and application ofhydrogen sulfide drugs and their derivatives,clinical prevention and treatment of NETs related diseases were reviewed.
作者
张立媛
赵雪颖
钟鑫
王育文
Zhang Liyuan;Zhao Xueying;Zhong Xin;Wang Yuwen(Department of Clinical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;Department of Pathophysiology,Harbin Medical University,Harbin 150081,China)
出处
《国际免疫学杂志》
CAS
2021年第4期448-452,共5页
International Journal of Immunology
基金
黑龙江省自然科学基金联合引导项目(LH2019C044)。
关键词
硫化氢
中性粒细胞胞外捕网
Hydrogen sulfide
Neutrophil extracellular traps
