摘要
糖尿病心肌病(diabetic cardiomyopathy,DCM)是一种特殊类型的心脏疾病,在一定程度上增加了糖尿病患者发生心力衰竭的风险,也是糖尿病患者死亡的主要原因之一。DCM的发病机制涉及多个方面,心肌细胞代谢紊乱(如高血糖和胰岛素抵抗)、心肌炎症和纤维化是DCM发病的基础,这些因素单独或联合作用于DCM的发生和发展。目前临床上尚无根治DCM的有效药物,研究疾病的发病机制在开发靶向治疗药物中具有重要意义。主要对当前DCM发病机制的研究进展展开综述,以期为DCM的早期预防和治疗提供理论基础。
Diabetic cardiomyopathy(DCM)is a special type of heart disease,which increases the risk of heart failure in diabetic patients to some extent and is also one of the main causes of death in diabetic patients.The pathogenesis of DCM involves many aspects.Myocardial cell metabolic disorders(such as hyperglycemia and insulin resistance),myocardial inflammation and fibrosis are the basis of the pathogenesis of DCM,and these factors act on the occurrence and development of DCM individually or in combination.At present,there is no effective drug for the radical cure of DCM in clinical practice,and the study of the pathogenesis of DCM is of great significance in the development of targeted therapy drugs.The pathogenesis of DCM was mainly reviewed in order to provide theoretical basis for the early prevention and treatment of DCM.
作者
廖敏
杨洛
王珍
郝亚荣
LIAO Min;YANG Luo;WANG Zhen;HAO Yarong(Department of Geriatrics,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《生物技术进展》
2021年第6期700-704,共5页
Current Biotechnology
基金
湖北省自然科学基金项目(2016CFB673)。
关键词
糖尿病心肌病
心力衰竭
高血糖
胰岛素抵抗
diabetic cardiomyopathy
heart failure
hyperglycemia
insulin resistance
