摘要
目的探究糖皮质激素治疗慢性肾炎的效果及对24 h尿蛋白定量及血浆白蛋白水平的影响。方法选取我院2018年3月至2019年3月收治的74例慢性肾炎患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组37例。对照组给予血管紧张素转氨酶抑制剂、抗血小板药物、控制高血压等常规对症治疗,观察组在对照组基础上给予糖皮质激素(部分患者加用环磷酰胺)治疗。比较两组患者的临床疗效,治疗前、后的肾功能指标、炎性因子水平、肝功能指标及不良反应发生情况。结果观察组的临床治疗总有效率明显高于对照组(P<0.05)。治疗后,观察的24 h尿蛋白定量、血肌酐、尿素氮、TNF-α及IL-8水平均明显低于对照组,血浆白蛋白水平明显高于对照组(P<0.05);两组的GPT水平无明显差异(P>0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论应用糖皮质激素(或加用环磷酰胺)冲击治疗慢性肾炎患者能够显著改善肾功能和炎性症状,且药物不会损伤患者肝功能,不良反应发生率较低。
Objective To investigate the effect of glucocorticoid in the treatment of chronic nephritis and its influences on 24-hour urinary protein quantification and plasma albumin level.Methods A total of 74 patients with chronic nephritis treated in our hospital from March 2018 to March 2019 were selected as the research objects.The patients were divided into control group and observation group using random number table method,with 37 cases in each group.The control group was given routine symptomatic treatment such as angiotensin aminotransferase inhibitor,antiplatelet drugs and control of hypertension,and the observation group was treated with glucocorticoid(some patients were added with cyclophosphamide)on the basis of the control group.The clinical efficacy,renal function indexes,inflammatory factors levels,liver function indexes before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,24-hour urinary protein quantification,serum creatinine,urea nitrogen,TNF-αand IL-8 levels in the observation group were significantly lower than those in the control group,and plasma albumin level was significantly higher than that in the control group(P<0.05);there was no significant difference in GPT level between the two groups(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Shock therapy with glucocorticoid(or added with cyclophosphamide)can significantly improve renal function and inflammatory symptoms in patients with chronic nephritis,and the drug will not damage liver function,and the incidence of adverse reactions is low.
作者
高世平
GAO Shiping(Kidney Medicine Department,the People's Hospital of Fugu County,Yulin 719400,China)
出处
《临床医学研究与实践》
2021年第33期75-77,共3页
Clinical Research and Practice
关键词
慢性肾炎
糖皮质激素
24
h尿蛋白定量
血浆白蛋白
chronic nephritis
glucocorticoid
24-hour urinary protein quantification
plasma albumin
