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醒脾养儿颗粒与酪酸梭菌活菌散治疗小儿消化不良性腹泻患儿的临床疗效研究 被引量:3

Clinical efficacy of Xingpi Yanger granule and clostridium butyricum powder in the treatment of children with dyspeptic diarrhea
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摘要 目的探究小儿消化不良性腹泻患儿应用醒脾养儿颗粒与酪酸梭菌活菌散治疗的效果。方法70例小儿消化不良性腹泻患儿,以硬币法分为观察组与对照组,每组35例。对照组接受醒脾养儿颗粒治疗,观察组接受醒脾养儿颗粒与酪酸梭菌活菌散治疗。比较两组患儿症状改善时间、治疗效果及治疗前后胃肠功能指标和血清炎症因子水平。结果观察组患儿腹泻、腹痛、大便形状、食欲不振改善时间分别为(2.21±1.03)、(2.36±1.05)、(7.46±1.22)、(3.51±1.28)d,均短于对照组的(3.69±1.28)、(3.56±1.28)、(9.84±1.55)、(4.86±1.55)d,差异具有统计学意义(P<0.05)。治疗后,观察组患儿胃动素、胃泌素、生长抑素、白细胞介素-6、肿瘤坏死因子-α水平分别为(402.63±11.84)ng/L、(81.63±8.15)ng/L、(48.63±1.88)ng/L、(16.25±2.15)μg/L、(4.15±1.52)pg/ml,均优于对照组的(455.64±10.98)ng/L、(96.46±9.65)ng/L、(40.05±2.51)ng/L、(20.15±4.63)μg/L、(8.15±1.98)pg/ml,差异具有统计学意义(P<0.05)。观察组患儿治疗总有效率为97.14%,高于对照组的77.14%,差异具有统计学意义(P<0.05)。结论小儿消化不良性腹泻患儿应用醒脾养儿颗粒与酪酸梭菌活菌散治疗可以取得理想效果,且可缩短症状改善时间,改善炎症指标和胃肠功能指标,值得推广。 Objective To investigate the effect of Xingpi Yanger granule and clostridium butyricum powder in the treatment of children with dyspeptic diarrhea.Methods A total of 70 children with dyspeptic diarrhea were divided into observation group and control group by coin method,with 35 cases in each group.The control group was treated with Xingpi Yanger granules,and the observation group was treated with Xingpi Yanger granules and clostridium butyricum powder.The symptom improvement time,therapeutic effect,gastrointestinal function indexes and serum inflammatory factor levels before and after treatment were compared between the two groups.Results The improvement time of diarrhea,abdominal pain,stool shape,and loss of appetite in the observation group were(2.21±1.03),(2.36±1.05),(7.46±1.22),and(3.51±1.28)d,respectively,which were shorter than(3.69±1.28),(3.56±1.28),(9.84±1.55),and(4.86±1.55)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of motilin,gastrin,somatostatin,interleukin-6,and tumor necrosis factor-αin the observation group were(402.63±11.84)ng/L and(81.63±8.15)ng/L,(48.63±1.88)ng/L,(16.25±2.15)μg/L,(4.15±1.52)pg/ml,which were better than(455.64±10.98)ng/L,(96.46±9.65)ng/L,(40.05±2.51)ng/L,(20.15±4.63)μg/L,(8.15±1.98)pg/ml in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 97.14%,which was higher than 77.14%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of Xingpi Yanger granule and clostridium butyricum powder has ideal effect on children with dyspeptic diarrhea,which can shorten symptom improvement time,improve the indexes of inflammation and gastrointestinal function,It is worthy of promotion.
作者 张瑶 ZHANG Yao(Department of Pediatrics,Changsha Maternal and Child Health Hospital,Changsha 410100,China)
出处 《中国现代药物应用》 2021年第21期15-17,共3页 Chinese Journal of Modern Drug Application
关键词 酪酸梭菌活菌散 醒脾养儿颗粒 消化不良性腹泻 小儿 疗效 Clostridium butyricum powder Xingpi Yanger granule Dyspeptic diarrhea Children Efficacy
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