摘要
目的探讨促性腺激素释放激素激动剂(GnRH-a)联合腹腔镜手术治疗卵巢子宫内膜异位囊肿的应用效果。方法回顾性选取2018年9月至2020年9月南京市江宁医院收治的60例卵巢子宫内膜异位囊肿患者为研究对象,根据治疗方案不同分为实验组(32例)与对照组(28例)。对照组采用腹腔镜手术直接治疗,实验组在对照组基础上给予GnRH-a治疗。比较两组前后的促黄体生成素(LH)、雌二醇(E_(2))、卵泡刺激素(FSH)水平,月经周期、月经时间及痛经程度变化,随访半年的复发率与妊娠情况。结果治疗后两组LH、E_(2)水平低于治疗前,且实验组LH、E_(2)水平低于对照组,差异有统计学意义(P<0.05),两组治疗前后FSH水平比较,差异无统计学意义(P>0.05)。治疗后两组的月经周期短于治疗前,月经时间长于治疗前,差异有统计学意义(P<0.05),而两组间治疗后月经周期、月经时间比较,差异无统计学意义(P>0.05)。随访半年,实验组的复发率低于对照组,术后妊娠率高于对照组,差异有统计学意义(P<0.05)。治疗后两组的痛经视觉模拟评分法(VAS)评分低于治疗前,且实验组的痛经VAS评分低于对照组,差异有统计学意义(P<0.05)。结论GnRH-a联合腹腔镜手术治疗卵巢子宫内膜异位囊肿患者,具有较好的应用效果,可以恢复患者激素水平,促进患者经期情况的恢复,减轻患者的痛经程度。
Objective To investigate the efficacy of gonadotropin-releasing hormone agonist(GnRH-a)combined with laparoscopic surgery in the treatment of ovarian endometriosis cyst.Methods A total of 60 patients with ovarian endometriosis cyst admitted to Nanjing Jiangning Hospital from September 2018 to September 2020 were retrospectively selected as the study subjects,and were divided into experimental group(32 cases)and control group(28 cases)according to different treatment regimens.The control group was treated directly with laparoscopic surgery,and the experimental group was treated with GnRH-a on the basis of the control group.The levels of luteinizing hormone(LH),estradiol(E_(2)),follicle stimulating hormone(FSH),menstrual cycle,menstrual time and dysmenorrhea were compared before and after the two groups.The recurrence rate and pregnancy status were followed up for half a year.Results After treatment,the LH and E_(2) levels in the two groups were lower than before,and the LH and E_(2) levels in the experimental group were lower than those in the control group,with statistical significance(P<0.05).There was no significant difference in FSH level between 2 groups before and after treatment(P>0.05).After treatment,the menstrual cycle of the two groups was shorter than before treatment,and the menstrual duration was longer than before treatment,with statistical significance(P<0.05).There was no significant difference in menstrual cycle and menstrual time between the two groups after treatment(P>0.05).Follow-up for half a year,the recurrence rate of the experimental group was lower than the control group,the postoperative pregnancy rate of the experimental group was higher than the control group,the difference was statistically significant(P<0.05).Visual analogue scale(VAS)score of dysmenorrhea in the two groups after treatment was lower than before,and VAS score of dysmenorrhea in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion GnRH-a combin
作者
孙博
刘莲花
SUN Bo;LIU Lian-hua(Department of Obstetrics and Gynecology,Nanjing Jiangning Hospital,Jiangsu Province,Nanjing211100,China)
出处
《中国当代医药》
CAS
2021年第32期126-129,共4页
China Modern Medicine
