摘要
目的探讨前后路手术联合利福平治疗脊柱结核的临床效果。方法回顾性分析2019年1月至12月九江市第三人民医院收治的60例脊柱结核患者的临床资料,依据治疗方法的不同将其分为联合组(n=32)、手术组(n=10)及单纯用药组(n=18)。单纯用药组采用利福平治疗,手术组采用前后路手术治疗,联合组采用前后路手术联合利福平治疗。比较三组的临床疗效、脊髓神经功能及Cobb角。结果联合组、手术组、单纯用药组的治疗总有效率(93.75%、60.00%、66.67%)比较,差异有统计学意义(P<0.05);联合组与手术组的治疗总有效率比较,差异无统计学意义(P>0.008);联合组与单纯用药组的治疗总有效率比较,差异无统计学意义(P>0.008);手术组与单纯用药组的治疗总有效率比较,差异无统计学意义(P>0.008);联合组术后的Frankel分级优于手术组和单纯用药组,差异有统计学意义(P<0.05);联合组的术后Cobb角[(10.85±2.16)°]小于手术组[(13.97±2.64)°]和单纯用药组[(15.12±1.89)°],差异有统计学意义(P<0.05)。结论脊柱结核患者采用前后路手术联合利福平治疗能够纠正后凸畸形,恢复脊髓神经功能,促进结核病灶愈合,可作为治疗脊柱结核的优选方案于临床推广。
Objective To explore the clinical efficacy of anterior and posterior surgery combined with Rifampin in the treatment of spinal tuberculosis.Methods The clinical data of 60 patients with spinal tuberculosis treated in the Third People′s Hospital of Jiujiang City from January to December 2019 were retrospectively analyzed.They were divided into the combined group(n=32),the surgery group(n=10)and the single medication group(n=18)according to different treatment methods.The single medication group was treated with Rifampin alone,the surgery group was treated with anterior and posterior surgery,and the combined group was treated with anterior and posterior surgery and Rifampin combined treatment.The clinical efficacy,spinal cord nerve function and Cobb angle were compared among the three groups.Results There were significant difference in the total effective rate of treatment in the combined group,the surgery group and the simple medication group(93.75%,60.00%,66.67%)(P<0.05).There was no significant difference in the total effective rate between the combined group and the surgery group(P>0.008).There was no significant difference in the total effective rate between the surgery group and the single medication group(P>0.008).Postoperative Frankel classification of the combined group were better than those of the surgery group and the simple medication group,and the differences were statistically significant(P<0.05).The Cobb angle of the combined group([10.85±2.16]°)were lower than those of the surgery group([13.97±2.64]°)and the simple medication group([15.12±1.89]°),and the differences were statistically significant(P<0.05).Conclusion Anterior and posterior surgery combined with Rifampin in the treatment of spinal tuberculosis can correct kyphosis,restore spinal cord nerve function,and promote the healing of tuberculosis lesions,which can be promoted in clinical practice as an optimal treatment for spinal tuberculosis.
作者
李忠
刘志红
戴珍珍
汪昌发
吴吉光
LI Zhong;LIU Zhi-hong;DAI Zhen-zhen;WANG Chang-fa;WU Ji-guang(Department of Orthopeadic Surgery,the Third People′s Hospital of Jiujiang City,Jiangxi Province,Jiujiang 332000,China)
出处
《中国当代医药》
CAS
2021年第32期79-82,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(202140231)。
关键词
脊柱结核
前后路手术
利福平
脊髓损伤程度
Spinal tuberculosis
Anterior and posterior surgery
Rifampin
Degree of spinal cord injury
